Evidence map›Paper›PMID 38565947›Full record

ArticleThe EMBO journal2024

ARGONAUTE10 controls cell fate specification and formative cell divisions in the Arabidopsis root.

Nabila El Arbi, Ann-Kathrin Schürholz, Marlene U Handl, Alexei Schiffner, Inés Hidalgo Prados, Liese Schnurbusch, Christian Wenzl, Xin'Ai Zhao, Jian Zeng, Jan U Lohmann and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Nabila El Arbi *Centre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5494-2229
Ann-Kathrin Schürholz *Centre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.
Marlene U Handl *Centre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0009-0005-5107-8902
Alexei SchiffnerCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9423-4382
Inés Hidalgo PradosCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4855-446X
Liese SchnurbuschCenter for Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0001-6212-1543
Christian WenzlCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.
Xin'Ai ZhaoCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0804-1619
Jian ZengCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.
Jan U LohmannCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3667-187X
Sebastian WolfCentre for Organismal Studies Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany. sebastian.wolf@zmbp.uni-tuebingen.de.ORCID http://orcid.org/0000-0003-0832-6315
Heidelberg University · DEUniversity of Tübingen · DE

Funding

Deutsche Forschungsgemeinschaft (DFG) CRC 1101-C09Deutsche Forschungsgemeinschaft (DFG) WO 1660/2-2Deutsche Forschungsgemeinschaft (DFG) WO 1660/6-1
6 · The paper itself

Abstract

A key question in plant biology is how oriented cell divisions are integrated with patterning mechanisms to generate organs with adequate cell type allocation. In the root vasculature, a gradient of miRNA165/6 controls the abundance of HD-ZIP III transcription factors, which in turn control cell fate and spatially restrict vascular cell proliferation to specific cells. Here, we show that vascular development requires the presence of ARGONAUTE10, which is thought to sequester miRNA165/6 and protect HD-ZIP III transcripts from degradation. Our results suggest that the miR165/6-AGO10-HDZIP III module acts by buffering cytokinin responses and restricting xylem differentiation. Mutants of AGO10 show faster growth rates and strongly enhanced survival under severe drought conditions. However, this superior performance is offset by markedly increased variation and phenotypic plasticity in sub-optimal carbon supply conditions. Thus, AGO10 is required for the control of formative cell division and coordination of robust cell fate specification of the vasculature, while altering its expression provides a means to adjust phenotypic plasticity.

Indexed as

ArabidopsisArabidopsis ProteinsArgonaute ProteinsCell DivisionGene Expression Regulation, PlantMicroRNAsPlant RootsCell DifferentiationXylemArabidopsis ProteinsArgonaute ProteinsAT5G43810 protein, ArabidopsisMicroRNAsArabidopsisCell FateCytokininPlant DevelopmentRobustness

Identifiers

PMID38565947
PMCPMC11066080
OpenAlexW4393396923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.