Evidence map›Paper›PMID 38565870›Full record

ArticleScientific reports2024

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates.

Maiju K Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M Riddy, Christopher J Langmead, Jyrki P Kukkonen, Henri Xhaard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Maiju K RinneDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, POB 56, 00014, Helsinki, Finland.
Lauri UrvasDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, POB 56, 00014, Helsinki, Finland.
Ilona MandrikaLatvian Biomedical Research and Study Centre, Riga, Latvia.
Dāvids FridmanisLatvian Biomedical Research and Study Centre, Riga, Latvia.
Darren M RiddyDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Christopher J LangmeadDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Jyrki P KukkonenBiochemistry and Cell Biology, Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, POB 66, 00014, Helsinki, Finland. jyrki.kukkonen@helsinki.fi.
Henri XhaardDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, POB 56, 00014, Helsinki, Finland. henri.xhaard@helsinki.fi.
University of Helsinki · FILatvian Biomedical Research and Study Centre · LVMonash University · AU

Funding

Academy of Finland 320210European Union, FP7-HEALTH-project GLORIA 602919
6 · The paper itself

Abstract

Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR). Here, molecular phylogeny suggested that CiOX is divergent from ATRs and human orexin receptors (hOX

Indexed as

Ciona intestinalisAnimalsCarrier ProteinsHEK293 CellsHumansOrexin ReceptorsOrexinsSignal TransductionVertebratesCarrier ProteinsOrexin ReceptorsOrexinsCalciumCiona intestinalisHypocretinOrexinReceptor binding

Identifiers

PMID38565870
PMCPMC10987541
OpenAlexW4393444072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.