Evidence map›Paper›PMID 38565572›Full record

ArticleScientific reports2024

Conditioned pain modulation (CPM) paradigm type affects its sensitivity as a biomarker of fibromyalgia.

A Gil-Ugidos, A Vázquez-Millán, N Samartin-Veiga, M T Carrillo-de-la-Peña

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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  10. A review of descending pain modulation in humans.Frontiers in pain research (Lausanne, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A Gil-UgidosDepartment of Clinical Psychology and Psychobiology, Brain and Pain Lab, University of Santiago de Compostela, Santiago de Compostela, Spain. antonio.gil.ugidos@usc.es.
A Vázquez-MillánDepartment of Clinical Psychology and Psychobiology, Brain and Pain Lab, University of Santiago de Compostela, Santiago de Compostela, Spain.
N Samartin-VeigaDepartment of Clinical Psychology and Psychobiology, Brain and Pain Lab, University of Santiago de Compostela, Santiago de Compostela, Spain.
M T Carrillo-de-la-PeñaDepartment of Clinical Psychology and Psychobiology, Brain and Pain Lab, University of Santiago de Compostela, Santiago de Compostela, Spain.
Universidade de Santiago de Compostela · ES

Funding

Agencia Estatal de Investigación PID2019-107986RB-I00Ministerio de Ciencia e Innovación PRE2020-091845
6 · The paper itself

Abstract

Fibromyalgia (FM) is a widespread chronic pain syndrome, possibly associated with the presence of central dysfunction in descending pain inhibition pathways. Conditioned Pain Modulation (CPM) has been proposed as a biomarker of FM. Nonetheless, the wide variety of methods used to measure CPM has hampered robust conclusions being reached. To clarify the validity of CPM as a biomarker of FM, we tested two CPM paradigms (parallel and sequential) in a sample of 23 female patients and 23 healthy women by applying test (mechanical) stimuli and conditioning (pressure cuff) stimuli. We evaluated whether CPM indices could correctly classify patients and controls, and we also determined the correlations between the indices and clinical variables such as symptomatology, disease impact, depression, quality of life, pain intensity, pain interference, fatigue and numbness. In addition, we compared the clinical status of CPM responders (efficient pain inhibitory mechanism) and non-responders. We observed that only parallel CPM testing correctly classified about 70% of patients with FM. In addition, more than 80% of healthy participants were found to be responders, while the rate was about 50% in the FM patients. The sequential CPM test was not as sensitive, with a decrease of up to 40% in the response rate for both groups. On the other hand, we did not observe any correlation between CPM measures and clinical symptoms. In summary, our findings demonstrate the influence of the CPM paradigm used and confirm that CPM may be a useful marker to complement FM diagnosis. However, the findings also cast doubts on the sensitivity of CPM as a marker of pain severity in FM.

Indexed as

Chronic PainFibromyalgiaBiomarkersFemaleHumansPain MeasurementPain ThresholdQuality of LifeBiomarkersChronic painConditioned pain modulationFibromyalgia

Identifiers

PMID38565572
PMCPMC10987675
OpenAlexW4393565554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.