ArticleProceedings of the National Academy of Sciences of the United States of America2024
The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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38 citing papers in PubMed, 57 citations in OpenAlex.
- Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.Renal failure · 2026Article
- Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis.Biomaterials · 2026Article
- Microparticles synthesized from itaconate polyesters enable metabolite delivery and elicit immunoregulatory outcomes.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Nrf2 deficiency in myeloid cells accelerates atherosclerosis by promoting the inflammatory response and impairing efferocytosis.Journal of advanced research · 2026Article
- Metabolite and nutrient regulation of macrophages in obesity and metabolic disease.Nature reviews. Immunology · 2026Review
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- Single-cell Technologies in Atherosclerosis: Uncovering Cellular Heterogeneity, Mechanisms, and Therapeutic Opportunities.Current atherosclerosis reports · 2026Review
- Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets.Journal of the American Heart Association · 2026Review
- Broiler Ascites Syndrome as a Potential Spontaneous Animal Model for Human Pulmonary Arterial Hypertension: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- ACOD1-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1.Redox biology · 2026Article
- Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation.Redox biology · 2026Article
- Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages.NAR molecular medicine · 2026Article
- IRG1/Itaconate Inhibits Microglial Senescence-Like Transition by Modulating Mitochondrial Dynamics through Rhoa Alkylation in Subarachnoid Hemorrhage.Aging and disease · 2026Article
- Mechanoresponsive reprogramming of tumor-associated macrophages during cancer progression.Frontiers in cell and developmental biology · 2026Review
- A single-cell and spatial atlas of plaque macrophage states in human atherosclerosis.Frontiers in immunology · 2026Review
- The role of glucose metabolic reprogramming in myocarditis and advances in therapeutic strategies.Frontiers in cardiovascular medicine · 2026Review
- ACOD1 regulates microglial arginine metabolism and inflammatory responses.Frontiers in immunology · 2026Article
- Itaconate modulates myeloid inflammation in myocardial infarction via metabolic and structural reprogramming.Genes & genomics · 2026Article
- Epigenetic metabolite lipid nanoparticles alleviate venous thrombosis via bone marrow reprogramming.Blood vessels, thrombosis & hemostasis · 2025Article
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Authors and funding
21 authors at 3 institutions in 2 countries.
Yannick Cyr *Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-0715-4112
Fazli K Bozal *Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-5181-2274
José Gabriel Barcia DuránCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Alexandra A C NewmanCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Letizia AmadoriCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Panagiotis SmyrnisCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Morgane GourvestCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Dayasagar DasCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Michael GildeaCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Ravneet KaurCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Tracy ZhangCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Kristin M WangCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Richard Von ItterCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
P Martin SchlegelDepartment of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich 81675, Germany.
Samantha D DupuisCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Bernard F SanchezCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Ann Marie SchmidtCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Edward A FisherCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0001-9802-143X
Coen van SolingenCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-5817-2003
Chiara GiannarelliCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.
Kathryn J MooreCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0003-2505-2547
New York University · USNYU Langone Health · USTechnical University of Munich · DE
Funding
Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Edward A Fisher · 2017 to 2026
$27.3MProject 3: RAGE/DIAPH1 interactions and cellular stressP01HL146367 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHMIDT, ANN MARIE · 2019 to 2023
$12.5MMolecular Regulation of Atherosclerosis Regression - RenewalR01HL084312 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A · 2006 to 2024
$11.4MNon-coding RNA regulation of cholesterol homeostasis and atherosclerosisR35HL135799 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J · 2017 to 2023
$6.7MTraining Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9MMechanisms of Platelet Activity in Vascular DiseaseR35HL144993 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2019 to 2025
$5.5MPlatelet Activity and Vascular Health in Systemic Lupus ErythematosusR01HL139909 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S, BUYON, JILL P · 2018 to 2022
$4.3MDissecting the role of CD8+ T cells in atherosclerosisR01HL153712 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GIANNARELLI, CHIARA · 2020 to 2024
$3.3MMechanisms of atherosclerotic cardiovascular complications in COVID19R01HL165258 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GIANNARELLI, CHIARA · 2022 to 2025
$3.1MTraining Program in Cell BiologyT32GM136542 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, SUSAN · 2020 to 2024
$3.0MELF1 - Molecular mechanisms of a novel transcription factor with broad antiviral activityR01AI143639 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 2019 to 2023
$2.5MSERPINs as a novel family of innate antiviral molecules - Resubmission - 1R21AI139374 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DITTMANN, MEIKE · 2019 to 2020
$466kNHLBI NIH HHS F30 HL167568NHLBI NIH HHS P01 HL131481NHLBI NIH HHS P01 HL146367NHLBI NIH HHS R01 HL084312NHLBI NIH HHS R01 HL139909NHLBI NIH HHS R01 HL153712NHLBI NIH HHS R01 HL165258NHLBI NIH HHS R35 HL135799NHLBI NIH HHS R35 HL144993NHLBI NIH HHS T32 HL098129NIAID NIH HHS R01 AI143639NIAID NIH HHS R21 AI139374NIGMS NIH HHS T32 GM136542
Abstract
Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of cardiovascular disease (CVD). Recently, metabolites have gained attention for their immunomodulatory properties, including itaconate, which is generated from the tricarboxylic acid-intermediate cis-aconitate by the enzyme Immune Responsive Gene 1 (IRG1/ACOD1). Here, we tested the therapeutic potential of the IRG1-itaconate axis for human atherosclerosis. Using single-cell RNA sequencing (scRNA-seq), we found that
Indexed as
AtherosclerosisPlaque, AtheroscleroticAnimalsCholesterolHumansHydro-LyasesInflammationLeukocytes, MononuclearLipidsMiceSuccinatesAcod1 protein, mouseCholesterolHydro-Lyasesitaconic acidLipidsSuccinatesatherosclerosisimmunometabolisminnate immunitymacrophageneutrophil
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.