ReviewPaediatric drugs2024
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention.
Review in Paediatric drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis
Risk Factors for Poor Prognosis in Neonatal Necrotizing Enterocolitis
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.Italian journal of pediatrics · 2025Pooled it
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Comparative efficacy of different single drugs to prevent necrotizing enterocolitis in preterm infants: an update systematic review and network meta-analysis.Frontiers in nutrition · 2024Pooled it
- Lactate, mean platelet volume, and nSOFA as combined predictors of perforated necrotizing enterocolitis and mortality in preterm infants: a retrospective cohort study.Annals of medicine · 2026Article
- Neonatal appendicitis with rectal bleeding: an unusual presentation.Irish journal of medical science · 2026Review
- Beyond early diagnosis: toward AI-enabled multi-omics prediction of necrotizing enterocolitis.World journal of pediatrics : WJP · 2026Article
- Review
- Identification and validation of a robust inflammation-related three-gene signature for the diagnosis of neonatal necrotizing enterocolitis via machine learning integration.Pediatric surgery international · 2026Article
- Clinical outcomes and determinants of intraoperative hyperlactatemia in neonates undergoing gastrointestinal surgery: a retrospective cohort analysis.Translational pediatrics · 2026Article
- Safety and Effectiveness of Probiotic Preparations: A Contemporary Review.Diseases (Basel, Switzerland) · 2026Review
- Identification of the expression of tRNA-derived small RNAs associated with necrotizing enterocolitis.Pediatric research · 2026Article
- From homeostasis to dysregulation: human milk, microbial metabolites, and the preterm intestinal microenvironment in necrotizing enterocolitis.Translational pediatrics · 2026Review
- Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Targeting PI3K/Akt/mTOR Pathway, Ki-67 and Endothelin Receptors by Ambrisentan in Juvenile Rat Intestinal Ischemia.International journal of molecular sciences · 2026Article
- Identification of diagnostic biomarkers for neonatal necrotizing enterocolitis via machine learning screening and single-cell virtual gene knockout validation.Journal of cell communication and signaling · 2026Article
- Deep learning feature-based model on abdominal radiography outperforms experts for early necrotizing enterocolitis diagnosis in neonates.European radiology · 2026Article
- Relationship between gut microbiota establishment patterns and the risk of necrotizing enterocolitis in preterm infants: a retrospective cohort study.Translational pediatrics · 2026Article
- For infants with surgical necrotizing enterocolitis, does primary anastomosis or stoma formation provide shorter parenteral nutrition?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- [Ultrasound diagnosis of necrotizing enterocolitis in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Long-term impact of necrotizing enterocolitis on somatosensory function in preterm born children.Pediatric research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, maternal and environmental factors, and intestinal ischemia) and reports treatment modalities surrounding NEC, including pain medications and common antibiotic combinations, the rationale for these combinations, and recent antibiotic stewardship approaches surrounding NEC treatment. This review also highlights the effect of early antibiotic exposure, infections, proton pump inhibitors (PPIs), and H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.