Evidence map›Paper›PMID 38564056›Full record

ArticleJournal of neurology2024

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.

Naila Makhani, Christine Lebrun-Frenay, Aksel Siva, Veronika Shabanova, Evangeline Wassmer, Jonathan D Santoro, Sona Narula, J Nicholas Brenton, Soe Mar, Francoise Durand-Dubief and 34 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 13 countries.

Naila MakhaniDepartment of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA. Naila.makhani@yale.edu.ORCID http://orcid.org/0000-0002-2325-130X
Christine Lebrun-FrenayCRCSEP Neurologie Pasteur 2, CHU de Nice, Université Cote d'Azur, UMR2CA (URRIS), Nice, France.
Aksel SivaNeuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.
Veronika ShabanovaDepartment of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA.
Evangeline WassmerNeurology Department, Birmingham Children's Hospital, Aston University, Birmingham, UK.
Jonathan D SantoroDepartment of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Sona NarulaChildren's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA.
J Nicholas BrentonDepartment of Neurology, University of Virginia, Charlottesville, USA.
Soe MarDepartment of Neurology, Washington University School of Medicine, St. Louis, USA.
Francoise Durand-DubiefService de sclérose en plaques, Pathologies de la myéline et Neuro-Inflammation, Hôpital Neurologique, Groupement Hospitalier Est, 59 Bd Pinel, 69677, BRON Cedex, France.
Helene ZephirInserm UMR-S 1172 LilNcog, Lille University Hospital FHU Precise, Lille University, Lille, France.
Guillaume MatheyDepartment of Neurology, Nancy University Hospital, 54035, Nancy, France.
Juan I RojasHospital Universitario de CEMIC, Buenos Aires, Argentina.
Jerome de SezeDepartment of Neurology, Hospital Hautepierre, CHU de Strasbourg and Clinical Investigation Center (CIC) INSERM 1434, Strasbourg, France.
Silvia TenembaumDepartment of Neurology, National Pediatric Hospital Dr. Juan P Garrahan, Buenos Aires, Argentina.
Robert Thompson StoneDepartment of Neurology, University of Rochester Medical Center, Rochester, USA.
Olivier CasezNeurology MS Clinic Grenoble, Grenoble Alpes University Hospital, Grenoble, France.
Clarisse Carra-DallièreNeurology MS Clinic, Montpellier University Hospital, 34295, Montpellier, France.
Rinze F NeuteboomDepartment of Neurology, Erasmus MC Rotterdam, Sophia's Children's Hospital, Rotterdam, The Netherlands.
Nusrat AhsanDepartment of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Hugo A ArroyoDepartment of Neurology, Hospital de Pediatría SAMIC. Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina.
Philippe CabreCentre Hospitalo Universitaire, Fort-de-France, Martinique.
Grace GombolayDivision of Neurology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Matilde IngleseDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), University of Genova, Genoa, Italy.
Celine LouapreAssistance Publique Hôpitaux de Paris, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, CIC Neurosciences, Sorbonne Université, Paris Brain Institute - ICM, Paris, France.
Monica MargoniDepartment of Neurosciences, Multiple Sclerosis Center of the Veneto Region, University Hospital-School of Medicine, Padua, Italy.
Filipe PalavraCenter for Child Development - Neuropaediatrics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Daniela PohlDivision of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
Aurélie RuetDepartment of Neurology, CHU Bordeaux, Bordeaux, France.
Eric ThouvenotDepartment of Neurology, Nîmes University Hospital, Nîmes, France.
Niklas TimbyDepartment of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden.
Mar TintoreNeurology Department, MS Center of Catalunya Cemcat, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), UVIC-Universitat Central de Catalunya, Barcelona, Spain.
Ugur UygunogluNeuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.
Wendy VargasDepartment of Neurology, Columbia University Medical Center, New York, USA.
Sunita VenkateswaranDivision of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Helene VerhelstDivision of Pediatric Neurology, Department of Pediatrics, University Hospital Ghent, Ghent, Belgium.
Ronny WickstromNeuropaediatric Unit, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Christina J AzevedoDepartment of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Orhun KantarciDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Eugene D ShapiroDepartment of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA.
Darin T OkudaDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, USA.
Daniel PelletierDepartment of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Observatoire Francophone de la Sclérose en Plaques (OFSEP), Société Francophone de la Sclérose en Plaques (SFSEP), Radiologically Isolated Syndrome Consortium (RISC), and the Pediatric Radiologically Isolated Syndrome Consortium (PARIS)
University of Southern California · USYale University · USCentre National de la Recherche Scientifique · FRChildren's Hospital of Eastern Ontario · CAGarrahan Hospital · ARInserm · FRIstanbul University-Cerrahpaşa · TRAston University · GBCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire de Martinique · MQChildren's Hospital of Philadelphia · USColumbia University Irving Medical Center · USEmory University · USErasmus MC · NLGhent University Hospital · BEHospitais da Universidade de Coimbra · PTHospital Universitario Austral · ARKarolinska University Hospital · SEMayo Clinic · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple SclerosisK23NS116225 · NINDS · UNIVERSITY OF VIRGINIA · PI BRENTON, JAMES NICHOLAS · 2021 to 2025
$962k
The Radiologically Isolated Syndrome in ChildrenK23NS101099 · NINDS · YALE UNIVERSITY · PI MAKHANI, NAILA · 2017 to 2022
$792k
Charles H. Hood Foundation Child Health Research AwardECTRIMS/MAGNIMS FellowshipNational Multiple Sclerosis Society Dr. Harry Weaver Neuroscience AwardNCATS NIH HHS KL2 TR001862NCATS NIH HHS KL2-TR001862NCATS NIH HHS KL2 TR002381NCATS NIH HHS KL2TR002381NCATS NIH HHS TL1 TR001864NCATS NIH HHS TL1-TR001864NCATS NIH HHS UL1-TR0001863NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002378NCATS NIH HHS UL1TR002378NINDS NIH HHS Intramural Research AwardNINDS NIH HHS K23 NS101099NINDS NIH HHS K23NS101099NINDS NIH HHS K23 NS116225NINDS NIH HHS K23NS116225
6 · The paper itself

Abstract

backgroundCerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown.

objectiveTo determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests.

methodsWe analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher's exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race).

resultsWe included 103 children with RIS (67% girls, median age = 14.9 y). Children ≥ 12 y were more likely than children < 12 y to have CSF obtained (58% vs. 21%, adjusted odds ratio [AOR] = 4.9, p = 0.03). Pre-2017, girls were more likely than boys to have CSF obtained (n = 70, 79% vs. 52%, AOR = 4.6, p = 0.01), but not more recently (n = 30, 75% vs. 80%, AOR = 0.2, p = 0.1; p = 0.004 for interaction). Spinal MRIs were obtained sooner in children ≥ 12 y (median 11d vs. 159d, p = 0.03).

conclusionsYounger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed.

Indexed as

Magnetic Resonance ImagingAdolescentAge FactorsChildDemyelinating DiseasesFemaleHumansLongitudinal StudiesMaleMultiple SclerosisSex FactorsSpinal CordChildrenMRIMultiple sclerosisPediatricRadiologically isolated syndrome

Identifiers

PMID38564056
PMCPMC11323224
OpenAlexW4393526577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.