Evidence map›Paper›PMID 38564019›Full record

ArticleAmino acids2024

Superior bioavailability of the calcium salt form of β-hydroxy-β-methylbutyrate compared with the free acid form.

Heitor Rodrigues Ribeiro, Felipe Gregório Jardim, Miriam Sanz Roldán, Vitor de Salles Painelli, Vinicius da Eira Silva, Aline Cristina Capparelli Tritto, Andressa Formalioni, Giovani Boldrini Custoias, Wagner Ribeiro Pereira, Marina Yazigi Solis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB).Journal of the International Society of Sports Nutrition · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Heitor Rodrigues Ribeiro *Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Felipe Gregório Jardim *Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Miriam Sanz RoldánFaculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP), São Paulo, Brazil.
Vitor de Salles PainelliStrength Training Study and Research Group, Institute of Health Sciences, Paulista University UNIP, São Paulo, Brazil.
Vinicius da Eira SilvaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
Aline Cristina Capparelli TrittoApplied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Andressa FormalioniApplied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Giovani Boldrini CustoiasApplied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Wagner Ribeiro PereiraApplied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Marina Yazigi SolisApplied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Felipe CarvalhoFaculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP), São Paulo, Brazil.
Ernani Pinto JuniorFaculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP), São Paulo, Brazil.
Guilherme Giannini ArtioliCentre for Bioscience, Department of Life Sciences, Manchester Metropolitan University, 215 John Dalton Building, Chester Street, Manchester, Lancashire, M1 5DG, UK. g.giannini.artioli@mmu.ac.uk.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 130205/2022-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/24434-6Programa Individual de Pesquisa para Docentes da Universidade Paulista 7-02-1166/2021
6 · The paper itself

Abstract

We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of β-hydroxy-β-methylbutyrate (HMB). Sixteen young individuals received the following treatments on three different occasions in a counterbalanced crossover fashion: (1) HMB-FA in clear capsules; (2) HMB-Ca in gelatine capsules; (3) HMB-Ca dissolved in water. All treatments provided 1 g of HMB. Blood samples were taken before and on multiple time points following ingestion. The following parameters were calculated: peak plasma (Cmax), time to peak (Tmax), slope of HMB appearance in blood, area under the curve (AUC), half-life time (t

Indexed as

CalciumValeratesWaterBiological AvailabilityHumansPharmaceutical Preparationsbeta-hydroxyisovaleric acidCalciumPharmaceutical PreparationsValeratesWaterAbsorptionBeta-hydroxyisovaleric acidPerformance-enhancing substancesPharmacokinetics

Identifiers

PMID38564019
PMCPMC10987370

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.