SynthesisInternational journal of colorectal disease2024
Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data.
Synthesis in International journal of colorectal disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The predictive value of multidimensional frailty instruments for postoperative adverse outcomes in cancer patients: a systematic review and meta-analysis.World journal of surgical oncology · 2026Pooled it
- The impact of anxiety and depression on hematologic malignancy outcomes: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Global research trends on gastrointestinal cancer and mental health (2004-2024): a bibliographic study.Frontiers in medicine · 2025Pooled it
- A network analysis examining mental health issues, including anxiety, depression, and post-traumatic stress disorder, in colorectal cancer patients.BMC psychology · 2026Article
- Ten-Year Outcomes in Colorectal Cancer-Competing Risks and Patient Vulnerability: A Prospective Multicenter Observational Study.Journal of clinical medicine · 2026Article
- Factors associated with anxiety in colorectal cancer survivors: a scoping review.Journal of cancer survivorship : research and practice · 2026Article
- BPX-Net: biomarker-preserved explainable networks for disease diagnosis and prognosis.BioData mining · 2026Article
- The relationship between perceived stress and depression in colorectal cancer patients: the mediating role of illness perception and the moderating role of self-efficacy.Frontiers in oncology · 2026Article
- Incidence of new-onset depression after colorectal cancer diagnosis and associated mortality: a population-based cohort study.BMJ oncology · 2026Article
- Depression and anxiety symptoms and their association with quality of life in patients with colorectal cancer: A cross-sectional study.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2026Article
- Dynamic screening for anxiety and depression in patients undergoing primary surgery for gastrointestinal cancer.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Article
- A barrier-forming gel for oral mucositis in head and neck cancers patients undergoing radiotherapy: randomized, controlled, multicenter trial.EClinicalMedicine · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundDepression and anxiety are common mental disorders in patients with colorectal cancer (CRC); however, it remains unclear whether they are related to cancer mortality.
methodBased on a systematic literature search, 12 eligible studies involving 26,907 patients with CRC were included in this study.
resultsUnivariate analysis revealed that anxiety was associated with an all-cause mortality rate of 1.42 (1.02, 1.96), whereas multivariate analysis revealed that anxiety was not associated with an all-cause mortality rate of 0.73 (0.39, 1.36). In univariate and multivariate analyses, depression was associated with all-cause mortality rates of 1.89 (1.68, 2.13) and 1.62 (1.27, 2.06), respectively, but not with the cancer-associated mortality rate of 1.16 (0.91, 1.48) in multivariate analyses. Multivariate subgroup analysis of depression and all-cause mortality showed that younger age (≤65 years), being diagnosed with depression/anxiety after a confirmed cancer diagnosis, and shorter follow-up time (<5 years) were associated with poor prognosis.
conclusionsOur study emphasizes the key roles of depression and anxiety as independent factors for predicting the survival of patients with CRC. However, owing to the significant heterogeneity among the included studies, the results should be interpreted with caution. Early detection and effective treatment of depression and anxiety in patients with CRC have public health and clinical significance.
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