Evidence map›Paper›PMID 38563872›Full record

ArticleEJNMMI radiopharmacy and chemistry2024

Human biodistribution and radiation dosimetry for the tau tracer [

Kun-Ju Lin, Shao-Yi Huang, Kuo-Lun Huang, Chin-Chang Huang, Ing-Tsung Hsiao

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03625128 (Phase 0 Evaluation of Clinical and Neuroimage), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03625128 early_phase1completednot on this map

Phase 0 Evaluation of Clinical and Neuroimage (18F-PM-PBB3 PET) Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls

TypeinterventionalSponsorChang Gung Memorial HospitalRan2018 to 2018Enrolled36ConditionsAlzheimer's Disease, Cortical Basal Syndrome, Frontotemporal Dementia, Progressive Supranuclear PalsyArmsF-18
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pilot Study of [Cells · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kun-Ju LinDepartment of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Shao-Yi HuangDepartment of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, No. 259, Wen-Hua 1St Road, Guishan Dist., Taoyuan City, 333, Taiwan.
Kuo-Lun HuangDepartment of Neurology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Chin-Chang HuangDepartment of Neurology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Ing-Tsung HsiaoDepartment of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. ihsiao@mail.cgu.edu.tw.ORCID http://orcid.org/0000-0002-5255-7498

Funding

Chang Gung Memorial Hospital BMRP488Chang Gung Memorial Hospital CMRPD1M0112Chang Gung Memorial Hospital CMRPG3J0364Chang Gung Memorial Hospital CMRPG3J0374Health Promotion Administration, Ministry of Health and Welfare 112-TDU-B-212-144005National Science and Technology Council 109-2314-B-182A-043-MY3National Science and Technology Council 112-2314-B-182-053National Science and Technology Council 112-2321-B-182A-004-National Science and Technology Council 112-2623-E-182A-001-NU
6 · The paper itself

Abstract

backgroundTau pathology plays a crucial role in neurodegeneration diseases including Alzheimer's disease (AD) and non-AD diseases such as progressive supranuclear palsy. Tau positron emission tomography (PET) is an in-vivo and non-invasive medical imaging technique for detecting and visualizing tau deposition within a human brain. In this work, we aim to investigate the biodistribution of the dosimetry in the whole body and various organs for the [

resultsFrom the biodistribution results, the elimination of [

conclusionsThe biodistribution study of [

trial registrationRetrospectively Registered at Clinicaltrials.gov (NCT03625128) on 12 July, 2018, https://clinicaltrials.gov/study/NCT03625128 .

Indexed as

[18F]FlorzolotauAlzheimer’s diseaseBiodistributionRadiation dosimetryTau PET

Identifiers

PMID38563872
PMCPMC10987466

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.