Evidence map›Paper›PMID 38563829›Full record

ArticleUrolithiasis2024

The impact of crystal phase transition on the hardness and structure of kidney stones.

Uta Michibata, Mihoko Maruyama, Yutaro Tanaka, Masashi Yoshimura, Hiroshi Y Yoshikawa, Kazufumi Takano, Yoshihiro Furukawa, Koichi Momma, Rie Tajiri, Kazumi Taguchi and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Urolithiasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Uta MichibataGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.
Mihoko MaruyamaGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan. maruyama@eei.eng.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-3453-8007
Yutaro TanakaGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.ORCID http://orcid.org/0000-0003-3154-170X
Masashi YoshimuraInstitute of Laser Engineering, Osaka University, 2-6, Yamadaoka, Suita City, 565-0871, Osaka, Japan.ORCID http://orcid.org/0000-0002-0770-1251
Hiroshi Y YoshikawaGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.ORCID http://orcid.org/0000-0003-0624-6039
Kazufumi TakanoGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5, Hangi-cho, Shimogamo, Sakyo-ku, Kyoto, 606-8522, Japan.ORCID http://orcid.org/0000-0002-7548-7314
Yoshihiro FurukawaDepartment of Earth Science, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.ORCID http://orcid.org/0000-0001-7241-530X
Koichi MommaNational Museum of Nature and Science, 4-1-1 Amakubo, Tsukuba, 305-0005, Japan.ORCID http://orcid.org/0000-0003-0659-0964
Rie TajiriTajiri Thin Section Laboratory, 3-1-11 Sannose, Higashiosaka, 577-0849, Osaka, Japan.ORCID http://orcid.org/0000-0001-8467-9580
Kazumi TaguchiDepartment of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho- cho, Mizuho-Ku, Nagoya, 467-8601, Japan.ORCID http://orcid.org/0000-0002-3092-5114
Shuzo HamamotoDepartment of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho- cho, Mizuho-Ku, Nagoya, 467-8601, Japan.ORCID http://orcid.org/0000-0002-9968-7468
Atsushi OkadaDepartment of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho- cho, Mizuho-Ku, Nagoya, 467-8601, Japan.ORCID http://orcid.org/0000-0003-2080-3794
Kenjiro KohriDepartment of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho- cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Takahiro YasuiDepartment of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho- cho, Mizuho-Ku, Nagoya, 467-8601, Japan.ORCID http://orcid.org/0000-0003-2197-2477
Shigeyoshi UsamiGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.ORCID http://orcid.org/0000-0002-9710-1718
Masayuki ImanishiGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.ORCID http://orcid.org/0000-0001-9395-1750
Yusuke MoriGraduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, 565-0871, Japan.ORCID http://orcid.org/0000-0003-2952-7458
Nagoya City University · JPThe University of Osaka · JPKyoto Prefectural University · JPNational Museum of Nature and Science · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-step process of crystal nucleation, growth, aggregation, and secondary transition. The secondary transition has been rather overlooked, and thus, the effects on the disease and the underlying mechanism remain unclear. Here, we show, by periodic micro-CT images of human kidney stones in an ex vivo incubation experiment, that the growth of porous aggregates of calcium oxalate dihydrate (COD) crystals triggers the hardening of the kidney stones that causes difficulty in lithotripsy of kidney stone disease in the secondary transition. This hardening was caused by the internal nucleation and growth of precise calcium oxalate monohydrate (COM) crystals from isolated urine in which the calcium oxalate concentrations decreased by the growth of COD in closed grain boundaries of COD aggregate kidney stones. Reducing the calcium oxalate concentrations in urine is regarded as a typical approach for avoiding the recurrence. However, our results revealed that the decrease of the concentrations in closed microenvironments conversely promotes the transition of the COD aggregates into hard COM aggregates. We anticipate that the suppression of the secondary transition has the potential to manage the deterioration of kidney stone disease.

Indexed as

Body FluidsKidney CalculiLithotripsyCalcium OxalateHardnessHumansCalcium OxalateCalcium oxalateExtracorporeal shock wave lithotripterKidney stonesMicrostructureSolution-mediated phase transitionX-ray micro-CT

Identifiers

PMID38563829
PMCPMC10987347
OpenAlexW4393431285

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.