ArticleDevelopment (Cambridge, England)2024
A geometrical model of cell fate specification in the mouse blastocyst.
Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data.PLoS biology · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities.NPJ systems biology and applications · 2026Article
- Generative epigenetic landscapes map the topology and topography of cell fates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Beyond metaphor: quantitative reconstruction of Waddington landscape and exploration of cellular behavior.Briefings in bioinformatics · 2025Review
- Reconstructing Waddington Landscape from Cell Migration and Proliferation.Interdisciplinary sciences, computational life sciences · 2025Article
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- FateNet: an integration of dynamical systems and deep learning for cell fate prediction.Bioinformatics (Oxford, England) · 2024Article
- Information content and optimization of self-organized developmental systems.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
The lineage decision that generates the epiblast and primitive endoderm from the inner cell mass (ICM) is a paradigm for cell fate specification. Recent mathematics has formalized Waddington's landscape metaphor and proven that lineage decisions in detailed gene network models must conform to a small list of low-dimensional stereotypic changes called bifurcations. The most plausible bifurcation for the ICM is the so-called heteroclinic flip that we define and elaborate here. Our re-analysis of recent data suggests that there is sufficient cell movement in the ICM so the FGF signal, which drives the lineage decision, can be treated as spatially uniform. We thus extend the bifurcation model for a single cell to the entire ICM by means of a self-consistently defined time-dependent FGF signal. This model is consistent with available data and we propose additional dynamic experiments to test it further. This demonstrates that simplified, quantitative and intuitively transparent descriptions are possible when attention is shifted from specific genes to lineages. The flip bifurcation is a very plausible model for any situation where the embryo needs control over the relative proportions of two fates by a morphogen feedback.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.