Evidence map›Paper›PMID 38563215›Full record

ArticleVeterinary ophthalmology2024

Validation of the eyeTelemed IOPvet indentation tonometer for use in dogs.

Lydia E Kapeller, Ava G Cabble, Phillip N Buckman, Christine D Harman, Amanda L Jacobson, Frank R Lawrence, András M Komáromy

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Veterinary ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lydia E KapellerDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Ava G CabbleDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Phillip N BuckmanDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Christine D HarmanDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Amanda L JacobsonDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Frank R LawrenceCenter for Statistical Training and Consulting, Michigan State University, East Lansing, Michigan, USA.
András M KomáromyDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.ORCID https://orcid.org/0000-0002-8845-0588
Michigan State University · US

Funding

Therapy development for open-angle glaucomasR01EY025752 · NEI · MICHIGAN STATE UNIVERSITY · PI KOMAROMY, ANDRAS · 2017 to 2021
$3.2M
Development of an IOP-lowering gene therapy treatment for glaucomaR01EY032478 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI KOMAROMY, ANDRAS, LIPINSKI, DANIEL MARK · 2022 to 2025
$2.6M
Short-term biomedical research training program for veterinary studentsT35OD016477 · OD · MICHIGAN STATE UNIVERSITY · PI COLLEEN Cosgrove HEGG, Andrea Noel Johnston · 2013 to 2026
$1.5M
BrightFocus Foundation G2022007SCollege of Agriculture and Natural Resources, Michigan State UniversityDepartment of Animal Science, Michigan State UniversityNEI NIH HHS R01 EY025752NEI NIH HHS R01-EY025752NEI NIH HHS R01 EY032478NEI NIH HHS R01-EY032478NIH HHS T35 OD016477Office of Undergraduate Research, Michigan State University
6 · The paper itself

Abstract

objectiveTo assess the accuracy of canine intraocular pressure (IOP) estimates from the eyeTelemed IOPvet indentation tonometer. ANIMALS STUDIED: Part 1 included 54 eyes from 28 Beagle dogs-23 ADAMTS10-mutants with open-angle glaucoma and 5 normals. Part 2 involved five normal canine ex vivo globes. PROCEDURE: Part 1 (in vivo) compared IOPvet estimates in normal and glaucomatous dogs to Reichert Tono-Vera® Vet rebound tonometry. The three IOPvet estimates were green (normal; <20 mmHg, according to the manufacturer), yellow (elevated; 20-30 mmHg), and red (high; >30 mmHg). In Part 2 (ex vivo), the pressure inside freshly enucleated normal canine eyes was progressively increased from 5 to 80 mmHg and compared to IOPvet estimates. Descriptive statistics compared IOPvet estimates to rebound tonometry and direct manometry, with the threshold from normal to glaucoma set at 30 mmHg.

resultsIn Part 1 (in vivo), normal pressures (≤30 mmHg) were mainly identified correctly as green or yellow-110 of 111 estimates, corresponding to a specificity of 99%. Only 16 of 125 affected estimates were correctly displayed in the >30-mmHg range; the remaining 109 showed ≤30 mmHg, corresponding to a sensitivity of 13%. In Part 2 (ex vivo), all normal pressures were correctly estimated with green, but 64 of 88 manometric IOPs >30 mmHg were falsely estimated as 20-30 mmHg.

conclusionsThe IOPvet is inaccurate in estimating canine IOP with a low sensitivity at identifying dogs with IOP > 30 mmHg. Canine-specific instrument revision is required to correctly identify elevated (yellow = 20-30 mmHg) and high (red >30 mmHg) IOPs.

Indexed as

Dog DiseasesIntraocular PressureTonometry, OcularAnimalsDogsFemaleGlaucomaGlaucoma, Open-AngleMaleReproducibility of ResultsADAMTS10‐open‐angle glaucomacanine glaucomadirect manometryglaucoma screeningintraocular pressuretonometry

Identifiers

PMID38563215
PMCPMC11445399
OpenAlexW4393427496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.