ArticleHypertension (Dallas, Tex. : 1979)2024
Coronary Microvascular Function Following Severe Preeclampsia.
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21 citing papers in PubMed, 25 citations in OpenAlex.
- Transforming Preeclampsia Care: Molecular Diagnostics and Therapeutic Innovations.Journal of the American Society of Nephrology : JASN · 2026Review
- Assessing Retinal Thickness and Associations with Cognitive Function in Women with History of Preeclampsia.Eye and brain · 2026Article
- Multimodal deep learning fusion model for assessment of fetal lung development in gestational diabetes mellitus and pre-eclampsia.Frontiers in endocrinology · 2026Article
- Coronary microvascular dysfunction in pregnancy: time to pay closer attention?Frontiers in cardiovascular medicine · 2026Review
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Coronary Microvascular Dysfunction: Bridging the Diagnosis-Treatment Divide in Women with INOCA-A Review.Journal of clinical medicine · 2025Review
- Endothelial Activation and Stress Index Is Associated With Adverse Maternal and Perinatal Outcomes in Preeclampsia.Journal of the American Heart Association · 2025Article
- Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Preeclampsia as a Risk Factor of Postmenopausal Cardiovascular Disease: A Cross-Sectional Study.Clinics and practice · 2025Article
- Examining the Disproportionate Burden of Microvascular Disease in Women.Current atherosclerosis reports · 2025Review
- Epidemiology and Pathophysiology of Preeclampsia: New Mechanistic Insights.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Long-Term Cardiovascular Risk and Maternal History of Pre-Eclampsia.Journal of clinical medicine · 2025Review
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.Circulation research · 2025Review
- Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.Circulation research · 2025Article
- Functional Adaptations in Coronary Reactivity following Healthy Pregnancy in Swine.Journal of vascular research · 2025Article
- Classification of Myocardial Infarction in Women With Hypertensive Disorders of Pregnancy.Journal of the American College of Cardiology · 2024Article
- Hypertensive Disorders of Pregnancy Increase the Risk for Myocardial Infarction: A Population-Based Study.Journal of the American College of Cardiology · 2024Article
- Association of Coronary Endothelial Function and Angiotensin Receptor Autoantibody With Preeclampsia Among Postpartum Women.Journal of the American Heart Association · 2024Article
- GPER Stimulation Attenuates Cardiac Dysfunction in a Rat Model of Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
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Authors and funding
25 authors at 5 institutions in 1 country.
Michael C HonigbergCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0001-8630-5021
Katherine E EconomyDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology (K.E.E.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-6359-0739
Maria A PabónDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-1883-0654
Xiaowen WangDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-5374-7832
Claire CastroCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0002-6309-1689
Jenifer M BrownDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-6647-639X
Sanjay DivakaranDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-0598-6502
Brittany N WeberDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-0177-2091
Leanne BarrettCardiovascular Imaging Program, Departments of Radiology and Medicine and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (J.M.B., S.D., B.N.W., L.B., A.P., A.Y.S., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-0667-8720
Anna PerilloCardiovascular Imaging Program, Departments of Radiology and Medicine and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (J.M.B., S.D., B.N.W., L.B., A.P., A.Y.S., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Anina Y SunCardiovascular Imaging Program, Departments of Radiology and Medicine and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (J.M.B., S.D., B.N.W., L.B., A.P., A.Y.S., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Tajmara AntoineCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.
Faranak FarrohiDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Brenda DocktorDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Emily S LauCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0001-9361-6397
Doreen DeFaria YehCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.
Pradeep NatarajanCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0001-8402-7435
Amy A SarmaCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.
Robert M WeisbrodWhitaker Cardiovascular Institute, Boston University School of Medicine, MA (R.M.W., N.M.H.).
Naomi M HamburgWhitaker Cardiovascular Institute, Boston University School of Medicine, MA (R.M.W., N.M.H.).ORCID 0000-0001-5504-5589
Jennifer E HoDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center (J.E.H.), Harvard Medical School, Boston.ORCID 0000-0002-7987-4768
Jason D RohCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0002-6999-6868
Malissa J WoodCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.
Nandita S ScottCardiology Division, Department of Medicine, Massachusetts General Hospital (M.C.H., C.C., T.A., E.S.L., D.D.Y., P.N., A.A.S., J.D.R., M.J.W., N.S.S.), Harvard Medical School, Boston.ORCID 0000-0003-3261-7833
Marcelo F Di CarliDivision of Cardiovascular Medicine, Department of Medicine (M.A.P., X.W., J.M.B., S.D., B.N.W., F.F., B.D., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-3119-025X
Brigham and Women's Hospital · USHarvard University · USBoston University · USBroad Institute · USBeth Israel Deaconess Medical Center · US
Funding
Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MWhole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7MEndothelial Cell Health Across the Spectrum of Cardiometabolic DiseaseR01HL168889 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Naomi Miriam Hamburg, Jennifer E Ho · 2023 to 2026
$3.1MMineralocorticoid receptor, coronary microvascular function, and cardiac efficiency in hypertensionR01HL162960 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Gail Kurr Adler, Marcelo F DI CARLI · 2023 to 2026
$3.1MIntegrating Artificial Intelligence for Optimal Analysis of CardiacPET/CTR01EB034586 · NIBIB · CEDARS-SINAI MEDICAL CENTER · PI DI CARLI, MARCELO F, SLOMKA, PIOTR J · 2022 to 2025
$2.9MLong-Term Endothelial Effects of COVID-19 in ObesityR01HL160003 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAMBURG, NAOMI MIRIAM, HO, JENNIFER E · 2022 to 2025
$2.8MPlacental Senescence in Peripartum CardiomyopathyR01HL170058 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JASON DAVID ROH · 2023 to 2026
$1.9MHFpEF Susceptibility in Women: The Role of InflammationK23HL159243 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Emily Lau · 2022 to 2026
$1.1MCardiac Perfusion, Structure, and Function across the Primary Aldosteronism SpectrumK23HL159279 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Jenifer Michelle Brown · 2022 to 2026
$1.0MAdvanced CV imaging and immunophenotyping to study coronary vascular health in psoriasisK23HL159276 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI WEBER, BRITTANY NICOLE · 2021 to 2025
$962kNHLBI NIH HHS K08 HL166687NHLBI NIH HHS K23 HL159243NHLBI NIH HHS K23 HL159276NHLBI NIH HHS K23 HL159279NHLBI NIH HHS K24 HL153669NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL160003NHLBI NIH HHS R01 HL162960NHLBI NIH HHS R01 HL168889NHLBI NIH HHS R01 HL170058NHLBI NIH HHS T32 HL094301NIBIB NIH HHS R01 EB034586
Abstract
backgroundPreeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating proangiogenic and antiangiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk.
methodsWomen with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group with normotensive deliveries underwent cardiac positron emission tomography within 4 weeks of delivery. A control group of premenopausal, nonpostpartum women was also included. Myocardial flow reserve, myocardial blood flow, and coronary vascular resistance were compared across groups. sFlt-1 (soluble fms-like tyrosine kinase receptor-1) and PlGF (placental growth factor) were measured at imaging.
resultsThe primary cohort included 19 women with severe preeclampsia (imaged at a mean of 15.3 days postpartum), 5 with normotensive pregnancy (mean, 14.4 days postpartum), and 13 nonpostpartum female controls. Preeclampsia was associated with lower myocardial flow reserve (β, -0.67 [95% CI, -1.21 to -0.13];
conclusionsIn this exploratory cross-sectional study, we observed reduced coronary microvascular function in the early postpartum period following preeclampsia, suggesting that systemic microvascular dysfunction in preeclampsia involves coronary microcirculation. Further research is needed to establish interventions to mitigate the risk of preeclampsia-associated cardiovascular disease.
Indexed as
Coronary CirculationPre-EclampsiaVascular Endothelial Growth Factor Receptor-1Vascular ResistanceAdultCoronary VesselsFemaleFractional Flow Reserve, MyocardialHumansMicrocirculationMicrovesselsPlacenta Growth FactorPositron-Emission TomographyPostpartum PeriodPregnancySeverity of Illness IndexPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1blood pressurecardiovascular diseasesheart failurepreeclampsiapregnancy
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