Evidence map›Paper›PMID 38563053›Full record

ArticleClinical chemistry and laboratory medicine2024

Evaluation of effects from hemoglobin variants on HbA

Yichuan Song, Anping Xu, Mo Wang, Jie Shi, Wenxuan Fu, Ling Ji, Rui Zhang

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Article in Clinical chemistry and laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yichuan SongDepartment of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.
Anping XuDepartment of Laboratory Medicine, 74573 Peking University Shenzhen Hospital , Shenzhen, Guangdong, P.R. China.ORCID 0000-0002-9827-7272
Mo WangDepartment of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.
Jie ShiDepartment of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.
Wenxuan FuDepartment of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.
Ling JiDepartment of Laboratory Medicine, 74573 Peking University Shenzhen Hospital , Shenzhen, Guangdong, P.R. China.
Rui ZhangDepartment of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.

Funding

Beijing Chaoyang Hospital Science and Technology Innovation Fund 22KCJJZD-7Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ZYLX202137
6 · The paper itself

Abstract

objectivesThe impact of seven hemoglobin variants (Hb Q-Thailand, Hb G-Honolulu, Hb Ube-2, Hb New York, Hb J-Bangkok, Hb G-Coushatta, and Hb E) on the outcome of HbA

methodsTwenty-nine normal and 112 variant samples were measured by LC/MS/MS, Sebia Capillarys 3 TERA, Intelligene Biosystems QuanTOF, Premier Hb9210, Arkray HA-8190V, Bio-Rad D-100, and Tosoh G11, then evaluated for correlation, consistency, and mean relative bias among six methods. The lowest biological variation bias of ±2.8 % was an acceptable standard.

resultsAll methods showed poor correlation and consistency with LC/MS/MS for Hb E. The unacceptable biases were observed for Capillarys 3 TERA (-14.4 to -3.7 % for Hb Q-Thailand, Hb Ube-2, Hb New York, Hb J-Bangkok and Hb E), QuanTOF (-8.3 to -2.9 % for Hb Ube-2, Hb New York and Hb G-Coushatta), Premier Hb9210 (-18.3 to -3.6 % for Hb Q-Thailand, Hb Ube-2, Hb New York, Hb J-Bangkok and Hb E), HA-8190V variant mode (-17.3 to 6.6 % for Hb G-Honolulu, Hb Ube-2, Hb New York, Hb G-Coushatta and Hb E). All variant samples showed larger biases than ±2.8 % comparing HA-8190V fast mode, D-100, and G11 with LC/MS/MS.

conclusionsThe accuracy of different HbA

Indexed as

Glycated HemoglobinTandem Mass SpectrometryChromatography, LiquidHemoglobins, AbnormalHumansGlycated Hemoglobinhemoglobin A1c protein, humanHemoglobins, AbnormalHbA1chemoglobin variantsmethod comparison

Identifiers

PMID38563053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.