Evidence map›Paper›PMID 38562953›Full record

ArticleVirus evolution2024

Evolutionary trajectory of diverse SARS-CoV-2 variants at the beginning of COVID-19 outbreak.

Jia-Xin Lv, Xiang Liu, Yuan-Yuan Pei, Zhi-Gang Song, Xiao Chen, Shu-Jian Hu, Jia-Lei She, Yi Liu, Yan-Mei Chen, Yong-Zhen Zhang

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jia-Xin LvState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Xiang LiuState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Yuan-Yuan PeiState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Zhi-Gang SongState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Xiao ChenCollege of Marine Sciences, South China Agricultural University, No. 483 Wushan Road, Tianhe District, Guangzhou, Guangdong 510642, China.
Shu-Jian HuState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Jia-Lei SheShanghai Public Health Clinical Center, No. 2901 Canglang Road, Jinshan District, Shanghai 210508, China.
Yi LiuShanghai Public Health Clinical Center, No. 2901 Canglang Road, Jinshan District, Shanghai 210508, China.
Yan-Mei ChenState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.
Yong-Zhen ZhangState Key Laboratory of Genetic Engineering, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences and Human Phenome Institute, Fudan University, No. 2005 Songhu Road, Yangpu District, Shanghai 200438, China.ORCID https://orcid.org/0000-0002-5961-3691
Fudan University · CNShanghai Public Health Clinical Center · CNSouth China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite extensive scientific efforts directed toward the evolutionary trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans at the beginning of the COVID-19 epidemic, it remains unclear how the virus jumped into and evolved in humans so far. Herein, we recruited almost all adult coronavirus disease 2019 (COVID-19) cases appeared locally or imported from abroad during the first 8 months of the outbreak in Shanghai. From these patients, SARS-CoV-2 genomes occupying the important phylogenetic positions in the virus phylogeny were recovered. Phylogenetic and mutational landscape analyses of viral genomes recovered here and those collected in and outside of China revealed that all known SARS-CoV-2 variants exhibited the evolutionary continuity despite the co-circulation of multiple lineages during the early period of the epidemic. Various mutations have driven the rapid SARS-CoV-2 diversification, and some of them favor its better adaptation and circulation in humans, which may have determined the waxing and waning of various lineages.

Indexed as

COVID-19Evolutionary trajectoryMutationsOutbreakSARS-CoV-2

Identifiers

PMID38562953
PMCPMC10984623
OpenAlexW4392473784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.