Evidence map›Paper›PMID 38562900›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy.

Steven L Brody, Jiehong Pan, Tao Huang, Jian Xu, Huihui Xu, Jeffrey Koenitizer, Steven K Brennan, Rashmi Nanjundappa, Thomas G Saba, Andrew Berical and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Steven L BrodyDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0002-0905-7527
Jiehong PanDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0003-2384-6845
Tao HuangDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Jian XuDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Huihui XuDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Jeffrey KoenitizerDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0002-4556-8455
Steven K BrennanDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0002-9445-8148
Rashmi NanjundappaDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0003-3621-4628
Thomas G SabaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, 48108, USA.ORCID 0000-0003-4753-9233
Andrew BericalCenter for Regenerative Medicine, Boston University, Boston, MA, 02118, USA.
Finn J HawkinsCenter for Regenerative Medicine, Boston University, Boston, MA, 02118, USA.ORCID 0000-0002-2246-6448
Xiangli WangDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Moe R MahjoubDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0001-8129-7464
Amjad HoraniDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, 48108, USA.ORCID 0000-0002-5352-1948
Susan K DutcherDepartment of Cell Biology and Physisology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.ORCID 0000-0001-5689-5753
Washington University in St. Louis · USBoston University · USUniversity of Michigan · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Patient-specific iPSCs to model and treat the inception of pulmonary fibrosisP01HL170952 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANDREW A WILSON · 2024 to 2026
$11.4M
REGULATION OF MOTILE CILIA ASSEMBLY IN LUNG DISEASER01HL128370 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, SUSAN K DUTCHER · 2015 to 2026
$6.9M
Genetic Analysis of Centrioles and CiliaR35GM131909 · NIGMS · WASHINGTON UNIVERSITY · PI SUSAN K DUTCHER · 2019 to 2026
$3.0M
Cellular and Molecular Features of Gene Mutations in Primary Ciliary DyskinesiaR01HL146601 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2019 to 2022
$2.3M
iPSC-Derived Airway Basal Cells to Model Human Airway Development and DiseaseR01HL139799 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAWKINS, FINN · 2018 to 2022
$2.1M
Structural and functional studies of axonemal microtubule inner proteins (MIPs)R01GM138854 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, RUI · 2020 to 2024
$2.0M
The Role of Dynein Motor Mutations in Motile Cilia DiseaseK08HL150223 · NHLBI · WASHINGTON UNIVERSITY · PI HORANI, AMJAD · 2020 to 2024
$797k
NCI NIH HHS P30 CA091842NHLBI NIH HHS K08 HL150223NHLBI NIH HHS P01 HL170952NHLBI NIH HHS R01 HL128370NHLBI NIH HHS R01 HL139799NHLBI NIH HHS R01 HL146601NIGMS NIH HHS R01 GM138854NIGMS NIH HHS R35 GM131909
6 · The paper itself

Abstract

Motile cilia have essential cellular functions in development, reproduction, and homeostasis. Genetic causes for motile ciliopathies have been identified, but the consequences on cellular functions beyond impaired motility remain unknown. Variants in

Indexed as

airwayciliadyneinNotch-signalingpericiliary barrierprimary ciliary dyskinesiaproteomics

Identifiers

PMID38562900
PMCPMC10983967
OpenAlexW4393048223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.