Evidence map›Paper›PMID 38562877›Full record

ArticlebioRxiv : the preprint server for biology2024

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

Prem Prakash, Purva Khodke, Muthukumar Balasubramaniam, Benem-Orom Davids, Thomas Hollis, Jamaine Davis, Jui Pandhare, Bajarang Kumbhar, Chandravanu Dash

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Prem PrakashDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, 37208, USA.
Purva KhodkeSunandan Divatia School of Science, NMIMS University, Mumbai, 400056, India.
Muthukumar BalasubramaniamDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, 37208, USA.
Benem-Orom DavidsDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York City, New York, 10032, USA.
Thomas HollisDepartment of Biochemistry and Center for Structural Biology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Jamaine DavisDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, 37208, USA.
Jui PandhareCenter for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee, 37208, USA.
Bajarang KumbharSunandan Divatia School of Science, NMIMS University, Mumbai, 400056, India.
Chandravanu DashDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, 37208, USA.ORCID 0000-0003-4466-8355
Meharry Medical College · USNarsee Monjee Institute of Management Studies · INColumbia University · USWake Forest University · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah, JAMES E HILDRETH · 2017 to 2026
$48.2M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2015 to 2026
$27.5M
Role of GRIN2 in ART and SUD associated neurological deficits.R01DA057204 · NIDA · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$3.7M
Defining the nuclear import pathways of HIV-1R01AI162694 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI CAMPBELL, EDWARD M · 2021 to 2024
$2.9M
Spatiotemporal Staging of the HIV-1 Preintegration complexR01AI170228 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$2.8M
Role of the Viral Capsid in HIV-1 IntegrationR01AI136740 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2019 to 2026
$2.2M
Enhancing Virology Training of Underrepresented Minority Students through Summer ResearchR25AI164610 · NIAID · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2021 to 2025
$1.8M
NIAID NIH HHS P30 AI110527NIAID NIH HHS P30 AI117970NIAID NIH HHS R01 AI136740NIAID NIH HHS R01 AI162694NIAID NIH HHS R01 AI170228NIAID NIH HHS R25 AI164610NIDA NIH HHS R01 DA057204NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

HIV-1 integration into the human genome is dependent on 3'-processing of the reverse transcribed viral DNA. Recently, we reported that the cellular Three Prime Repair Exonuclease 1 (TREX1) enhances HIV-1 integration by degrading the unprocessed viral DNA, while the integration-competent 3'-processed DNA remained resistant. Here, we describe the mechanism by which the 3'-processed HIV-1 DNA resists TREX1-mediated degradation. Our kinetic studies revealed that the rate of cleavage (

Identifiers

PMID38562877
PMCPMC10983988
OpenAlexW4393013188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.