Evidence map›Paper›PMID 38562874›Full record

ArticlebioRxiv : the preprint server for biology2024

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.

Meghan J Price, Annee D Nguyen, Corinne Haines, César D Baëta, Jovita Byemerwa, Debarati Murkajee, Sandeep Artham, Vardhman Kumar, Catherine Lavau, Suzanne Wardell and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Meghan J PriceDepartment of Neurosurgery, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Annee D NguyenDepartment of Neurosurgery, Duke University Medical Center, University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5550-9053
Corinne HainesDepartment of Molecular Genetics, Ohio State University, 1060 Carmack Road, Columbus, OH 43210, USA.
César D BaëtaDepartment of Neurosurgery, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Jovita ByemerwaDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Debarati MurkajeeDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Sandeep ArthamDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Vardhman KumarDepartment of Biomedical Engineering, Duke University Medical Center, Durham, NC, USA.
Catherine LavauDepartment of Neurosurgery, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Suzanne WardellDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Shyni VargheseDepartment of Biomedical Engineering, Duke University Medical Center, Durham, NC, USA.
C Rory GoodwinDepartment of Neurosurgery, Duke University Medical Center, University School of Medicine, Durham, NC, USA.
Duke University · USThe Ohio State University · US

Funding

Neuro-immune modulation of pain in health and diseaseR01DE031053 · NIDCR · DUKE UNIVERSITY · PI Christopher Ryan Donnelly · 2022 to 2026
$3.3M
NIDCR NIH HHS R01 DE031053
6 · The paper itself

Abstract

Survival for metastatic breast cancer is low and thus, continued efforts to treat and prevent metastatic progression are critical. Estrogen is shown to promote aggressive phenotypes in multiple cancer models irrespective of estrogen receptor (ER) status. Similarly, UDP-Glucose 6-dehydrogenase (UGDH) a ubiquitously expressed enzyme involved in extracellular matrix precursors, as well as hormone processing increases migratory and invasive properties in cancer models. While the role of UGDH in cellular migration is defined, how it intersects with and impacts hormone signaling pathways associated with tumor progression in metastatic breast cancer has not been explored. Here we demonstrate that UGDH knockdown blunts estrogen-induced tumorigenic phenotypes (migration and colony formation) in ER+ and ER- breast cancer

Indexed as

breast cancercancerestrogenextravasationmigrationsurvivalUDP-6-glucose dehydrogenaseUGDH

Identifiers

PMID38562874
PMCPMC10983948
OpenAlexW4393056950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.