ArticlebioRxiv : the preprint server for biology2024
Regulation of Diseases-Associated Microglia in the Optic Nerve by Lipoxin B
Shubham Maurya, Maggie Lin, Shruthi Karnam, Tanirika Singh, Matangi Kumar, Emily Ward, Jeremy Sivak, John G Flanagan, Karsten Gronert
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 3 countries.
Shubham MauryaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.ORCID 0000-0002-2263-9791 Maggie LinHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Shruthi KarnamHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Tanirika SinghHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Matangi KumarHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Emily WardHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Jeremy SivakDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
John G FlanaganHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Karsten GronertHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, United States.
Dr.Heiko Pult Optometry and Vision Research · DEBerkeley College · USUniversity Health Network · CA
Funding
UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Xiaohua Gong · 1985 to 2026
$16.4MTRAINING PROGRAM IN VISION SCIENCET32EY007043 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 1985 to 2026
$12.9MHomeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4MA Zeiss LSM 710 confocal microscope for the Biological Imaging Facility at the US10RR026866 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUZIN, STEVEN EARL · 2010 to 2010
$419kNCRR NIH HHS S10 RR026866NEI NIH HHS P30 EY003176NEI NIH HHS R01 EY030218NEI NIH HHS T32 EY007043
6 · The paper itselfAbstract
Background: The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B Methods: Cellular targets and signaling of LXB Results: Single-cell transcriptomics identified microglia as a primary target for LXB Conclusion: We identified early and dynamic changes in the microglia functional phenotype, reactivity, and induction of a unique CD74 microglia population in the distal optic nerve as key features of ocular hypertension-induced neurodegeneration. Our findings establish microglia regulation as a novel LXB
Indexed as
Glaucomalipoxinsmicroglia reactivityneurodegenerationoptic nerveretina
Identifiers
PMID38562864
PMCPMC10983965
OpenAlexW4393014284
What OpenQuestion holds
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