ArticlemedRxiv : the preprint server for health sciences2024
Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
55 authors at 20 institutions in 7 countries.
Samvida S VenkateshBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0000-0001-7680-1208
Laura B L WittemansNovo Nordisk Research Centre Oxford, Oxford, United Kingdom.
Duncan S PalmerBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0000-0002-0824-0047
Nikolas A BayaBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0000-0002-4681-374X
Teresa FerreiraBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.
Barney HillBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0000-0002-7417-1393
Frederik Heymann LassenBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.
Melody J ParkerBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0009-0002-9829-2816
Saskia ReibeBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.ORCID 0000-0003-3638-7529
Ahmed ElhakeemMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-7637-6360
Karina BanasikNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Mie T BruunDepartment of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Bitten A JensenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
Anders JuulDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen, Denmark.
Christina MikkelsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-2945-6197
Henriette S NielsenDepartment of Obstetrics and Gynecology, The Fertility Clinic, Hvidovre University Hospital, Copenhagen, Denmark.
Sisse R OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ole B PedersenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Palle D RohdeGenomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-4347-8656
Erik SorensenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Henrik UllumStatens Serum Institut, Copenhagen, Denmark.
David WestergaardNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Asgeir HaraldssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0001-5364-7877
Hilma HolmdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0002-9517-6636
Ingileif JonsdottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Isleifur OlafssonDepartment of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Thora SteingrimsdottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0003-1846-6274
Gudmar ThorleifssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0003-4623-9087
Jessica FigueredoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1416-2644
Minna K KarjalainenInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3184-3775
Anu PasanenResearch Unit of Clinical Medicine, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.ORCID 0000-0001-7460-5086
Benjamin M JacobsCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University London, London, EC1M 6BQ, United Kingdom.ORCID 0000-0002-6023-6010
Nikki HubersDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.
Genes & Health Research Team
Estonian Biobank Research Team
Estonian Health Informatics Research Team
DBDS Genomic Consortium
FinnGen
Margaret LippincottHarvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Abigail FraserMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Deborah A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Nicholas J TimpsonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Mette NyegaardGenomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-4973-8543
Kari StefanssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0003-1676-864X
Reedik MagiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-2964-6011
Hannele LaivuoriInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3212-7826
David A van HeelBlizard Institute, Queen Mary University London, London, E1 2AT, United Kingdom.ORCID 0000-0002-0637-2265
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.
Ravikumar BalasubramanianHarvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Stephanie B SeminaraHarvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Yee-Ming ChanHarvard Medical School, Boston, Massachusetts, United States of America.
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1501-9030
Cecilia M LindgrenBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.
deCODE Genetics (Iceland) · ISUniversity of Copenhagen · DKUniversity of Oxford · GBHarvard University · USUniversity of Bristol · GBCentre for Human Genetics · GBUniversity of Helsinki · FIBoston Children's Hospital · USBroad Institute · USQueen Mary University of London · GBReykjavík University · ISAalborg University · DKAalborg University Hospital · DKAarhus University · DKCopenhagen University Hospital · DKJohn Radcliffe Hospital · GBNovo Nordisk Foundation · DKOdense University Hospital · DKOulu University Hospital · FIStatens Serum Institut · DK
Funding
The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI TALKOWSKI, MICHAEL E · 2021 to 2025
$7.8MKisspeptin: A Novel Regulator of Insulin in PregnancyK23HD097296 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LIPPINCOTT, MARGARET FLYNN · 2019 to 2023
$864kFDA HHS R01 FD007843NICHD NIH HHS K23 HD097296NICHD NIH HHS P50 HD104224Wellcome Trust
Abstract
Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.