ArticlebioRxiv : the preprint server for biology2024
Structural and genetic diversity in the secreted mucins,
Elizabeth G Plender, Timofey Prodanov, PingHsun Hsieh, Evangelos Nizamis, William T Harvey, Arvis Sulovari, Katherine M Munson, Eli J Kaufman, Wanda K O'Neal, Paul N Valdmanis and 3 more
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 5 institutions in 2 countries.
Elizabeth G PlenderDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-5063-8737 Timofey ProdanovInstitute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.ORCID 0000-0001-7469-6651 PingHsun HsiehDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Evangelos NizamisDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA 98195, USA.
William T HarveyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-0646-7528 Arvis SulovariDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-4354-9020 Katherine M MunsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0001-8413-6498 Eli J KaufmanDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0001-8553-210X Wanda K O'NealMarsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, 27599, North Carolina, USA.ORCID 0000-0003-2412-5943 Paul N ValdmanisDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0001-8840-6969 Tobias MarschallInstitute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.ORCID 0000-0002-9376-1030 Jesse D BloomDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-8246-4014 University of Washington · USHoward Hughes Medical Institute · USDüsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DEUniversity of North Carolina at Chapel Hill · US
Funding
Identifying and Characterizing the Full Spectrum of Haplotype-resolved Structural Variation in Human GenomesU24HG007497 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Evan Eichler, Jan Oliver Korbel · 2019 to 2026
$17.2MSequence and Assembly of Segmental DuplicationsR01HG002385 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2001 to 2026
$13.3MAn Integrative Analysis of Structural Variation for the 1000 Genomes ProjectU41HG007497 · NHGRI · JACKSON LABORATORY · PI LEE, CHARLES · 2013 to 2017
$13.0MSequence-resolved structural variation of human genomesR01HG010169 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2018 to 2026
$4.5MNHGRI NIH HHS R01 HG002385NHGRI NIH HHS R01 HG010169NHGRI NIH HHS U24 HG007497NHGRI NIH HHS U41 HG007497
6 · The paper itselfAbstract
The secreted mucins MUC5AC and MUC5B play critical defensive roles in airway pathogen entrapment and mucociliary clearance by encoding large glycoproteins with variable number tandem repeats (VNTRs). These polymorphic and degenerate protein coding VNTRs make the loci difficult to investigate with short reads. We characterize the structural diversity of
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PMID38562829
PMCPMC10983947
OpenAlexW4392979104
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