ArticlebioRxiv : the preprint server for biology2024
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination.
Emma R Wilson, Gustavo Della-Flora Nunes, Shichen Shen, Seth Moore, Joseph Gawron, Jessica Maxwell, Umair Syed, Edward Hurley, Meghana Lanka, Jun Qu and 4 more
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 6 institutions in 3 countries.
Emma R WilsonDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-8069-0173 Gustavo Della-Flora NunesDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-9323-3556 Shichen ShenDepartment of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Seth MooreDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Joseph GawronDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-8088-1298 Jessica MaxwellDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Umair SyedDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Edward HurleyDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-1967-8933 Meghana LankaDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA.
Jun QuDepartment of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-1346-6809 Laurent DesaubryCenter of Research in Biomedicine of Strasbourg, Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0002-1192-2970 Lawrence WrabetzDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-3360-1032 Yannick PoitelonDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA.ORCID 0000-0001-9868-1569 M Laura FeltriDepartment of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-2276-9182 Jacobs Institute · USAlbany Medical Center Hospital · USUniversity at Buffalo, State University of New York · USInserm · FRUniversity of Cambridge · GBUniversity of Colorado System · US
Funding
Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve RepairR01NS110627 · NINDS · ALBANY MEDICAL COLLEGE · PI POITELON, YANNICK · 2020 to 2024
$2.1MThe prohibitin family and their function in myelination and axonal healthR01NS100464 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FELTRI, M. LAURA · 2016 to 2020
$1.7MYAP/TAZ in Schwann Cells as Potential Therapeutic Targets in CMT1A and HNPP.F30NS125928 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MOORE, SETH MICHAEL · 2022 to 2023
$66kNINDS NIH HHS F30 NS125928NINDS NIH HHS R01 NS100464NINDS NIH HHS R01 NS110627
6 · The paper itselfAbstract
Schwann cells are critical for the proper development and function of the peripheral nervous system, where they form a mutually beneficial relationship with axons. Past studies have highlighted that a pair of proteins called the prohibitins play major roles in Schwann cell biology. Prohibitins are ubiquitously expressed and versatile proteins. We have previously shown that while prohibitins play a crucial role in Schwann cell mitochondria for long-term myelin maintenance and axon health, they may also be present at the Schwann cell-axon interface during development. Here, we expand on this work, showing that drug-mediated modulation of prohibitins
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OpenAlexW4393054071
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