Evidence map›Paper›PMID 38562800›Full record

ArticlebioRxiv : the preprint server for biology2024

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.

Caleb Cheng, Jing Hu, Rahul Mannan, Rupam Bhattacharyya, Nicholas J Rossiter, Brian Magnuson, Jasmine P Wisniewski, Yang Zheng, Lanbo Xiao, Chungen Li and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 2 countries.

Caleb ChengMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Jing HuMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Rahul MannanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Rupam BhattacharyyaMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Nicholas J RossiterCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Brian MagnusonMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Jasmine P WisniewskiMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Yang ZhengMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Lanbo XiaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Chungen LiState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC.
Dominik AwadDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Tongchen HeMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Yi BaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Yuping ZhangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Xuhong CaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Zhen WangState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC.
Rohit MehraMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Pietro MorlacchiAgilent Technologies, Inc., Lexington, MA, USA.
Vaibhav SahaiRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Marina Pasca di MaglianoRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Yatrik M ShahRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Ke DingState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC.
Yuanyuan QiaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9282-3415
University of Michigan · USShanghai Institute of Organic Chemistry · CNHoward Hughes Medical Institute · USAgilent Technologies (United States) · USCentral South University · CN

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Exploring Precision Oncology: From Gene Fusions to lncRNAsR35CA231996 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 2018 to 2024
$6.4M
Michigan-VUMC Biomarker Characterization CenterU2CCA271854 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARUL M CHINNAIYAN · 2022 to 2026
$5.4M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6M
Understanding the mechanisms of iron addiction in colon cancerR01CA245546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2020 to 2024
$2.3M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
Targeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA244931NCI NIH HHS R01 CA245546NCI NIH HHS R01 CA248160NCI NIH HHS R35 CA231996NCI NIH HHS R37 CA237421NCI NIH HHS U2C CA271854NIGMS NIH HHS T32 GM145470
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism

Indexed as

autophagyKRASlysosomeMAPKpancreatic cancerPIKfyve

Identifiers

PMID38562800
PMCPMC10983929
OpenAlexW4392978739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.