Evidence map›Paper›PMID 38562780›Full record

ArticlebioRxiv : the preprint server for biology2024

Reduced STMN2 and pathogenic TDP-43, two hallmarks of ALS, synergize to accelerate motor decline in mice.

Kelsey L Krus, Ana Morales Benitez, Amy Strickland, Jeffrey Milbrandt, A Joseph Bloom, Aaron DiAntonio

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kelsey L KrusDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-4425-2141
Ana Morales BenitezDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-1021-5262
Amy StricklandDepartment of Genetics, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-5809-8464
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-5477-7689
A Joseph BloomDepartment of Genetics, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-6731-5539
Aaron DiAntonioDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, United States, 63110.ORCID 0000-0002-7262-0968
Washington University in St. Louis · USJames S. McDonnell Foundation · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
DISSECTION OF SARM1-INDUCED AXON DEGENERATION AND CELL DEATHR01NS087632 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio, JEFFREY D MILBRANDT · 2014 to 2026
$6.4M
Regulation of axonal degeneration by the DLK kinaseR37NS065053 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio · 2020 to 2026
$4.3M
SARM1 functional polymorphisms and their contribution to ALS riskR01NS119812 · NINDS · WASHINGTON UNIVERSITY · PI BLOOM, ADAM JOSEPH, DIANTONIO, AARON · 2021 to 2025
$2.9M
Regulating NAD Metabolism to Inhibit Axon Degeneration in Neurodegenerative DiseasesRF1AG013730 · NIA · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2017 to 2017
$2.8M
NCATS NIH HHS UL1 TR002345NIA NIH HHS RF1 AG013730NINDS NIH HHS R01 NS087632NINDS NIH HHS R01 NS119812NINDS NIH HHS R37 NS065053
6 · The paper itself

Abstract

Pathological TDP-43 loss from the nucleus and cytoplasmic aggregation occurs in almost all cases of ALS and half of frontotemporal dementia patients.

Indexed as

ALSFTDneurodegenerationneuropathyStathminSTMN2TARDBPTDP-43

Identifiers

PMID38562780
PMCPMC10983882
OpenAlexW4393053980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.