Evidence map›Paper›PMID 38562777›Full record

ArticleResearch square2024

A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity.

Eugene V Mosharov, Ayelet M Rosenberg, Anna S Monzel, Corey A Osto, Linsey Stiles, Gorazd B Rosoklija, Andrew J Dwork, Snehal Bindra, Ya Zhang, Masashi Fujita and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Eugene V MosharovDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-0229-7114
Ayelet M RosenbergDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Anna S MonzelDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Corey A OstoDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA.
Linsey StilesDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA.ORCID 0000-0002-1514-458X
Gorazd B RosoklijaNew York State Psychiatric Institute, New York, NY, USA.
Andrew J DworkNew York State Psychiatric Institute, New York, NY, USA.
Snehal BindraDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Ya ZhangCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Masashi FujitaCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Madeline B MarianiNew York State Psychiatric Institute, New York, NY, USA.
Mihran BakalianNew York State Psychiatric Institute, New York, NY, USA.
David SulzerDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-7632-0439
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8057-2505
Vilas MenonCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4096-8601
Orian S ShirihaiDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA.ORCID 0000-0001-8466-3431
J John MannNew York State Psychiatric Institute, New York, NY, USA.
Mark UnderwoodNew York State Psychiatric Institute, New York, NY, USA.
Maura BoldriniNew York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0003-3574-7641
Michel Thiebaut de SchottenBrain Connectivity and Behavior Laboratory, Paris, France; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, France.ORCID 0000-0002-0329-1814
Martin PicardDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USUniversity of California, Los Angeles · USCentre National de la Recherche Scientifique · FRColumbia University · US

Funding

Deconstructing and modeling the single cell architecture of the Alzheimer brainRF1AG057473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2017 to 2018
$4.0M
Mitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human BrainRF1AG076821 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2022 to 2022
$2.4M
NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG076821
6 · The paper itself

Abstract

Mitochondrial oxidative phosphorylation (OxPhos) powers brain activity

Indexed as

anatomical mappingbrain voxelizationmitochondriaMRIneuroimagingOxPhosphenotypingsingle-cell RNA sequencing

Identifiers

PMID38562777
PMCPMC10984021
OpenAlexW4393069294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.