ArticleResearch square2024
A potential neuromodulation target for PTSD in Veterans derived from focal brain lesions.
Shan Siddiqi, Noah S Philip, Stephan Palm, Amanda Arulpragasam, Jennifer Barredo, Heather Bouchard, Michael Ferguson, Jordan Grafman, Rajendra Morey, Michael Fox and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 9 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 2 institutions in 1 country.
Noah S PhilipAlpert Medical School of Brown University, Center for Neurorestoration and Neurotechnology, Providence VA Medical Center.ORCID 0000-0002-4889-8775 Amanda ArulpragasamBrown University Alpert School of Medicine.
Jennifer BarredoBrown University Alpert School of Medicine.
Heather BouchardDuke University School of Medicine.
Michael FergusonHarvard Medical School.
Rajendra MoreyDuke University School of Medicine.
David CarreonAcacia Mental Health.
Brigham and Women's Hospital · USShirley Ryan AbilityLab · US
Funding
Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI GREENBERG, BENJAMIN D · 2019 to 2023
$11.3MUsing human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9MRepetitive TMS-induced modulation of cortical excitability in ADR01MH115949 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2018 to 2022
$3.2MTreating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognitionR01AG060987 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2019 to 2023
$3.0MLow intensity focused ultrasound: a new paradigm for depression and anxietyU01MH123427 · NIMH · OCEAN STATE RESEARCH INSTITUTE, INC. · PI PHILIP, NOAH STEPHEN · 2021 to 2024
$2.4MWhite Matter Damage in Subconcussive Blast ExposureR01NS086885 · NINDS · DUKE UNIVERSITY · PI MOREY, RAJENDRA A · 2014 to 2018
$1.7MPersonalized circuit-based neuromodulation targets for depressionK23MH121657 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI SIDDIQI, SHAN · 2020 to 2024
$978kTransdiagnostic memory, mood and motor circuits in Alzheimer's and neurodegenerative diseaseR56AG069086 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2021
$873kTargeted modulation of symptom-specific brain circuits with transcranial magnetic stimulationR21MH126271 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2022
$492kVA RR&D Center for Neurorestoration and NeurotechnologyI50RX002864 · VA · PROVIDENCE VA MEDICAL CENTER · PI BENJAMIN D GREENBERG, LEIGH R HOCHBERG · 2018 to 2026
–Pilot Testing of Theta-Burst Neuromodulation for Chronic PTSDI21RX002032 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2016 to 2018
–Mapping Subject-Specific Structural and Functional Connectivity to Parse the Unique Contributions of Subconcussive Blast, Mild TBI, and PTSDI01CX002293 · VA · DURHAM VA MEDICAL CENTER · PI RAJENDRA A MOREY · 2021 to 2026
–CSRD VA I01 CX002293NIA NIH HHS R01 AG060987NIA NIH HHS R56 AG069086NIGMS NIH HHS P20 GM130452NIMH NIH HHS K23 MH121657NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH115949NIMH NIH HHS R21 MH126271NIMH NIH HHS U01 MH123427NINDS NIH HHS R01 NS086885RRD VA I21 RX002032RRD VA I50 RX002864
6 · The paper itselfAbstract
Neuromodulation trials for PTSD have yielded mixed results, and the optimal neuroanatomical target remains unclear. We analyzed three datasets to study brain circuitry causally linked to PTSD in military Veterans. After penetrating traumatic brain injury (n=193), lesions that reduced probability of PTSD were preferentially connected to a circuit including the medial prefrontal cortex (mPFC), amygdala, and anterolateral temporal lobe (cross-validation p=0.01). In Veterans without lesions (n=180), PTSD was specifically associated with connectivity within this circuit (p<0.01). Connectivity change within this circuit correlated with PTSD improvement after transcranial magnetic stimulation (TMS) (n=20) (p<0.01), even though the circuit was not directly targeted. Finally, we directly targeted this circuit with fMRI-guided accelerated TMS, leading to rapid resolution of symptoms in a patient with severe lifelong PTSD. All results were independent of depression severity. This lesion-based PTSD circuit may serve as a neuromodulation target for Veterans with PTSD.
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PMID38562753
PMCPMC10984085
OpenAlexW4392948708
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