Evidence map›Paper›PMID 38562738›Full record

ArticlebioRxiv : the preprint server for biology2024

Dysregulated Ca

Kai-Ting Huang, Larry E Wagner, Takahiro Takano, Xiao-Xuan Lin, Harini Bagavant, Umesh Deshmukh, David I Yule

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kai-Ting HuangDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY. 14526.ORCID 0000-0003-3138-3406
Larry E WagnerDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY. 14526.
Takahiro TakanoDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY. 14526.
Xiao-Xuan LinDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY. 14526.
Harini BagavantArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13 Street, Oklahoma City, OK 73104.
Umesh DeshmukhArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13 Street, Oklahoma City, OK 73104.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY. 14526.ORCID 0000-0002-6743-0668
University of Rochester · USOklahoma Medical Research Foundation · US

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR56DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI YULE, DAVID I · 2007 to 2007
$395k
NIDCR NIH HHS R01 DE014756NIDCR NIH HHS R56 DE014756
6 · The paper itself

Abstract

Saliva is essential for oral health. The molecular mechanisms leading to physiological fluid secretion are largely established, but factors that underlie secretory hypofunction, specifically related to the autoimmune disease Sjögren's syndrome (SS) are not fully understood. A major conundrum is the lack of association between the severity of inflammatory immune cell infiltration within the salivary glands and glandular hypofunction. In this study, we investigated in a mouse model system, mechanisms of glandular hypofunction caused by the activation of the stimulator of interferon genes (STING) pathway. Glandular hypofunction and SS-like disease were induced by treatment with 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid (DMXAA), a small molecule agonist of murine STING. Contrary to our expectations, despite a significant reduction in fluid secretion in DMXAA-treated mice,

Indexed as

Ca2+ signalingDMXAA-induced SS mouse modelmitochondrial dysfunctionSalivary gland hypo-functionSjögren’s syndromeTMEM16a channelXerostomia

Identifiers

PMID38562738
PMCPMC10983907
OpenAlexW4392935180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.