Evidence map›Paper›PMID 38562727›Full record

ArticlebioRxiv : the preprint server for biology2024

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.

S A Rial, Z You, A Vivoli, D Sean, Amal Al-Khoury, G Lavoie, M Civelek, A Martinez-Sanchez, Roux Pp, T M Durcan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

S A RialDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.
Z YouThe Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
A VivoliDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.
D SeanDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.
Amal Al-KhouryDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.
G LavoieInstitute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada.
M CivelekDepartment of Biomedical Engineering, University of Virginia, Charlottesville, United States.ORCID 0000-0002-8141-0284
A Martinez-SanchezSection of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK.ORCID 0000-0001-5142-2527
Roux PpInstitute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada.ORCID 0000-0002-5962-0250
T M DurcanThe Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.ORCID 0000-0003-3942-1956
G E LimDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.ORCID 0000-0003-3850-3757

Funding

The role of adipocyte KLF14 in Metabolic SyndromeR01DK118287 · NIDDK · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE · 2018 to 2022
$2.4M
NIDDK NIH HHS R01 DK118287
6 · The paper itself

Abstract

We previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but the temporal specificity of its action during adipocyte differentiation remains unclear. To decipher if 14-3-3ζ exerts its regulatory functions on mature adipocytes or on adipose precursor cells (APCs), we generated

Indexed as

14-3-3ζadipocyte progenitor cellsadipogenesisAdipose tissueATAC-seqdifferentiationscaffold proteins

Identifiers

PMID38562727
PMCPMC10983991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.