ArticleResearch square2024
Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures.
Sanjay Jain, Xueyi Chen, Bhavatharini Arun, Oscar Nino Meza, Mona Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth Tucker and 4 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 4 institutions in 2 countries.
Bhavatharini ArunUniversity of Maryland School of Pharmacy.
Oscar Nino MezaJohns Hopkins University School of Medicine.
Mona SarhanJohns Hopkins University School of Medicine.
Medha SinghJohns Hopkins University School of Medicine.
Kishor ManeRutgers New Jersey Medical School.
Maunank ShahJohns Hopkins University.
Elizabeth TuckerJohns Hopkins University School of Medicine.
Laurence CarrollJohns Hopkins University School of Medicine.
Charles PeloquinUniversity of Florida College of Pharmacy.
Vijay IvaturiUniversity of Maryland, Baltimore.
Johns Hopkins University · USUniversity of Maryland, Baltimore · USRutgers Sexual and Reproductive Health and Rights · NLRutgers, The State University of New Jersey · US
Funding
Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0MMeasuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8MMolecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2MNovel Imaging and host-directed therapy in pediatric CNS TBK08AI139371 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUCKER, ELIZABETH WINANS · 2019 to 2023
$994kMeasuring Intralesional Bedaquiline Exposures in Cavitary TB Using Noninvasive In Vivo PET ImagingR21AI149760 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY, ORDONEZ, ALVARO ANDRES · 2020 to 2021
$450kNHLBI NIH HHS R01 HL131829NIAID NIH HHS K08 AI139371NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIAID NIH HHS R21 AI149760
6 · The paper itselfAbstract
Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration. Here, we performed first-in-human dynamic
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PMID38562706
PMCPMC10984015
OpenAlexW4393032250
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