Evidence map›Paper›PMID 38562704›Full record

ArticlebioRxiv : the preprint server for biology2024

A Developmental Mechanism to Regulate Alternative Polyadenylation in an Adult Stem Cell Lineage.

Lorenzo Gallicchio, Neuza R Matias, Fabian Morales-Polanco, Iliana Nava, Sarah Stern, Yi Zeng, Margaret T Fuller

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lorenzo GallicchioDepartment of Developmental Biology, Stanford University School of Medicine, Stanford USA.ORCID 0000-0002-5040-0139
Neuza R MatiasDepartment of Developmental Biology, Stanford University School of Medicine, Stanford USA.ORCID 0000-0003-1548-037X
Fabian Morales-PolancoDepartment of Biology, Stanford University School of Humanities and Sciences, Stanford USA.ORCID 0000-0002-7695-3081
Iliana NavaDepartment of Developmental Biology, Stanford University School of Medicine, Stanford USA.
Sarah SternDepartment of Developmental Biology, Stanford University School of Medicine, Stanford USA.ORCID 0000-0002-6518-7289
Yi ZengDepartment of Genetics, Stanford University School of Medicine, USA.
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford USA.ORCID 0000-0002-3804-4987
Stanford Medicine · USStanford University · US

Funding

Regulation of proliferation and differentiation in the male germ line adult stem cell lineageR35GM136433 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER · 2020 to 2026
$5.9M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIGMS NIH HHS R35 GM136433NIH HHS S10 OD010580
6 · The paper itself

Abstract

Alternative Cleavage and Polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3'UTRs from the same genetic locus, potentially impacting mRNA translation, localization and stability. Developmentally regulated APA can thus make major contributions to cell-type-specific gene expression programs as cells differentiate. During

Indexed as

Alternative PolyadenylationCellular DifferentiationCleavage factor Complex IIDevelopmentDrosophilamRNA processingSpermatogenesis

Identifiers

PMID38562704
PMCPMC10983978
OpenAlexW4392966625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.