ArticlebioRxiv : the preprint server for biology2025
Atomically accurate de novo design of antibodies with RFdiffusion.
Open access · greenAbstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 179 citations in OpenAlex.
- The Role of AI-Driven De Novo Protein Design in the Exploration of the Protein Functional Universe.Biology · 2025Review
- Inference and design of antibody specificity: From experiments to models and back.PLoS computational biology · 2024Article
Corrections and comments
- Updated by
Authors and funding
32 authors at 6 institutions in 3 countries.
Nathaniel R BennettDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8590-1454
Joseph L WatsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5492-0249
Robert J RagotteDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6463-1595
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4297-7824
DéJenaé L SeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2550-2459
Connor WeidleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9354-2276
Riti BiswasDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3766-1980
Yutong YuDepartment of Biomedical Engineering, University of California; Irvine, CA, USA.
Ellen L ShrockDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2484-4374
Russell AultDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-5430-5366
Philip J Y LeungDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1801-8968
Buwei HuangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0762-7178
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9254-9249
John TamMolecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Kenneth D CarrDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0009-0005-1929-3952
Benedikt SingerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0009-0009-5691-2117
Cameron CriswellDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0009-0006-2853-3847
Basile I M WickyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2501-7875
Dionne VafeadosInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2560-8907
Mariana Garcia SanchezInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Ho Min KimCenter for Biomolecular and Cellular Structure, Institute for Basic Science (IBS), Daejeon, 34126, Republic of Korea.ORCID 0000-0003-0029-3643
Susana Vázquez TorresDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8226-8227
Sidney ChanInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1617-0464
Shirley M SunCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0007-6764-5750
Timothy SpearDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yi SunCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Keelan O'ReillyDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
John M MarisDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8088-7929
Nikolaos G SgourakisCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3655-3902
Roman A MelnykMolecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Chang C LiuDepartment of Biomedical Engineering, University of California; Irvine, CA, USA.ORCID 0000-0002-3290-2880
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217
University of Washington · USChildren's Hospital of Philadelphia · USHoward Hughes Medical Institute · USKorea Advanced Institute of Science and Technology · KRUniversity of California, Irvine · USUniversity of Toronto · CA
Funding
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2020 to 2024
$15.9MTRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6MMaking antibody generation rapid, scalable, and democratic through machine learning and continuous evolutionR01CA260415 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KRUSE, ANDREW, LIU, CHANG C · 2020 to 2024
$8.4MNextGen - CHOPOT2CA278687 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOHN M MARIS · 2022 to 2026
$2.7MSynthetic genetic systems for rapid biomolecular evolution in vivoR35GM136297 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, CHANG C · 2020 to 2024
$2.4MMolecular Biophysics Training ProgramT32GM153507 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury, Justin M Kollman · 2024 to 2026
$1.7MVisual Sciences Training Program (VSTP)T32EY032448 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Philip David Kiser, Chang C Liu · 2022 to 2026
$656kGates Foundation INV-010680NCI NIH HHS OT2 CA278687NCI NIH HHS R01 CA260415NEI NIH HHS T32 EY032448NIA NIH HHS U19 AG065156NIGMS NIH HHS R35 GM136297NIGMS NIH HHS T32 GM008268NIGMS NIH HHS T32 GM153507
Abstract
Despite the central role that antibodies play in modern medicine, there is currently no method to design novel antibodies that bind a specific epitope entirely
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.