Evidence map›Paper›PMID 38562378›Full record

ArticleFrontiers in genetics2024

Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan.

Aigul Sharip, Saule Rakhimova, Askhat Molkenov, Ainur Ashenova, Ulan Kozhamkulov, Ilyas Akhmetollayev, Andrei Zinovyev, Yuri Zhukov, Marat Omarov, Mukhtar Tuleutaev and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Ethnic genomic diversity in esophageal squamous cell carcinoma.World journal of gastrointestinal oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Aigul Sharip *Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Saule Rakhimova *Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Askhat MolkenovCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ainur AshenovaCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ulan KozhamkulovCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ilyas AkhmetollayevNational Center for Biotechnology, Astana, Kazakhstan.
Andrei ZinovyevInstitut Curie, PSL Research University, Paris, France.
Yuri ZhukovMultidisciplinary Medical Center, Astana, Kazakhstan.
Marat OmarovMultidisciplinary Medical Center, Astana, Kazakhstan.
Mukhtar TuleutaevMultidisciplinary Medical Center, Astana, Kazakhstan.
Venera RakhmetovaDepartment of Internal Diseases, Astana Medical University, Astana, Kazakhstan.
Joseph D TerwilligerSergiеvsky Center, Columbia University, New York, NY, United States.
Joseph H LeeSergiеvsky Center, Columbia University, New York, NY, United States.
Zhaxybay ZhumadilovCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ainur AkilzhanovaCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ulykbek Kairov *Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Nazarbayev University · KZAstana Medical University · KZColumbia University · USInstitut Curie · FRNational Center for Biotechnology · KZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer in Central Asia, often diagnosed at advanced stages. Understanding population-specific patterns of ESCC is crucial for tailored treatments. This study aimed to unravel ESCC's genetic basis in Kazakhstani patients and identify potential biomarkers for early diagnosis and targeted therapies. ESCC patients from Kazakhstan were studied. We analyzed histological subtypes and conducted in-depth transcriptome sequencing. Differential gene expression analysis was performed, and significantly dysregulated pathways were identified using KEGG pathway analysis (

Indexed as

analysis of differentially expressed genesbioinformaticsesophageal squamous cell carcinomaKazakhstannext-generation sequencingRNA-seqtranscriptomics

Identifiers

PMID38562378
PMCPMC10982404
OpenAlexW4392923449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.