ArticleFrontiers in human neuroscience2024
Opportunities and obstacles in non-invasive brain stimulation.
Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-invasive brain stimulation for treating cognitive and neuropsychiatric non-motor symptoms in Parkinson's disease and atypical parkinsonism: a systematic review and meta-analysis of randomized controlled trials.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- A patient-specific, 3D printed neurostimulator enabling focal transcranial electrical stimulation and EEG at home.Journal of neuroengineering and rehabilitation · 2025Trial
- An integrated investigation of systemic and localized pathophysiological mechanisms of stroke and multimodal therapeutic strategies.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials.Lasers in medical science · 2026Article
- Mapping the Global Trajectory and Key Trends of Temporal Interference Stimulation.Bioengineering (Basel, Switzerland) · 2026Article
- The Use of Non-Invasive Brain Stimulation Techniques in Subjects with Parkinson's Disease and Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2026Review
- Current landscape of newer non-invasive brain stimulation in psychiatric disorders across South Asia.Indian journal of psychiatry · 2025Review
- An intelligent closed-loop CES for depression treatment using brain signals and machine learning.MethodsX · 2025Article
- Identification of Reliable Target Brain Regions for Enhancing Object-Location Memory by Brain Stimulation.Brain and behavior · 2025Article
- Neurostimulation in Childhood Epilepsy.Indian pediatrics · 2025Review
- Efficacy of brain stimulation therapies across psychiatric, movement, and cognitive disorders: an umbrella review synthesizing meta-analyses of randomized controlled trials.EClinicalMedicine · 2025Article
- Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation.Exploration of neuroscience · 2025Article
- Syncing the brain's networks: dynamic functional connectivity shifts from temporal interference.Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive brain stimulation (NIBS) is a complex and multifaceted approach to modulating brain activity and holds the potential for broad accessibility. This work discusses the mechanisms of the four distinct approaches to modulating brain activity non-invasively: electrical currents, magnetic fields, light, and ultrasound. We examine the dual stochastic and deterministic nature of brain activity and its implications for NIBS, highlighting the challenges posed by inter-individual variability, nebulous dose-response relationships, potential biases and neuroanatomical heterogeneity. Looking forward, we propose five areas of opportunity for future research: closed-loop stimulation, consistent stimulation of the intended target region, reducing bias, multimodal approaches, and strategies to address low sample sizes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.