Evidence map›Paper›PMID 38562197›Full record

ArticleBulletin of the World Health Organization2024

Target product profiles: leprosy diagnostics.

Petra Kukkaro, Sundeep Chaitanya Vedithi, David J Blok, Wim H van Brakel, Annemieke Geluk, Aparna Srikantam, David Scollard, Linda B Adams, Mathias Duck, Sunil Anand and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Bulletin of the World Health Organization, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
    Review
  4. Leprosy.Nature reviews. Disease primers · 2024
    Review
  5. Target product profiles: leprosy diagnostics.Bulletin of the World Health Organization · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Petra KukkaroNovartis Pharma AG, Basel, Switzerland.
Sundeep Chaitanya VedithiDepartment of Biochemistry, University of Cambridge, Cambridge, England.
David J BlokDepartment of Public Health, Erasmus University Medical Center, Rotterdam, Kingdom of the Netherlands.
Wim H van BrakelUntil No Leprosy Remains, Amsterdam, Kingdom of the Netherlands.
Annemieke GelukDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Kingdom of the Netherlands.
Aparna SrikantamClinical and Laboratory Research Division, Blue Peter Public Health and Research Centre-LEPRA Society, Hyderabad, India.
David ScollardNational Hansen's Disease Program, Baton Rouge, United States of America (USA).
Linda B AdamsNational Hansen's Disease Program, Baton Rouge, United States of America (USA).
Mathias DuckThe Leprosy Mission International, Brentford, England.
Sunil AnandAmerican Leprosy Missions, Hyderabad, India.
Andie TuckerThe Task Force for Global Health, Inc, Decatur, USA.
Israel CruzNational School of Public Health, Instituto de Salud Carlos III, Madrid, Spain.
Vrr PemmarajuGlobal Leprosy Programme, WHO Regional Office for South-East Asia, New Delhi, India.
Daniel Argaw DagneDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Kingsley AsieduDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Christopher HannaGlobal Project Partners, Oakland, USA.
World Health Organization · CHAmerican Leprosy Missions · USEscuela Nacional de Sanidad · ESNovartis (Switzerland) · CHUniversity of Cambridge · GBWorld Health Organization Regional Office for South-East Asia · IN

Funding

World Health Organization 001
6 · The paper itself

Abstract

The World Health Organization (WHO) aims to reduce new leprosy cases by 70% by 2030, necessitating advancements in leprosy diagnostics. Here we discuss the development of two WHO's target product profiles for such diagnostics. These profiles define criteria for product use, design, performance, configuration and distribution, with a focus on accessibility and affordability. The first target product profile outlines requirements for tests to confirm diagnosis of leprosy in individuals with clinical signs and symptoms, to guide multidrug treatment initiation. The second target product profile outlines requirements for tests to detect

Indexed as

LeprosyEarly DiagnosisHumansModels, StatisticalMycobacterium lepraeSensitivity and Specificity

Identifiers

PMID38562197
PMCPMC10976862
OpenAlexW4394609915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.