Evidence map›Paper›PMID 38562030›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024

Clinical and genetic analysis of essential hypertension with mitochondrial tRNA

Meili Guo, Yunfan He, Ade Chen, Zaishou Zhuang, Xiaoyong Pan, Minxin Guan

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meili GuoClinical Laboratory, Cangnan County People's Hospital, Wenzhou 325800, Zhejiang Province, China. guomeili2000@163.com.
Yunfan HeInstitute of Genetics, Zhejiang University, Zhejiang Provincial Key Lab of Genetic and Developmental Disorders, Hangzhou 310058, China.
Ade ChenClinical Laboratory, Cangnan County People's Hospital, Wenzhou 325800, Zhejiang Province, China.
Zaishou ZhuangClinical Laboratory, Cangnan County People's Hospital, Wenzhou 325800, Zhejiang Province, China.
Xiaoyong PanClinical Laboratory, Cangnan County People's Hospital, Wenzhou 325800, Zhejiang Province, China.
Minxin GuanInstitute of Genetics, Zhejiang University, Zhejiang Provincial Key Lab of Genetic and Developmental Disorders, Hangzhou 310058, China. gminxin88@zju.edu.cn.
People's Hospital of Cangzhou · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the role of m.4435A>G and

methodsA hypertensive patient with m.4435A>G and

resultsMitochondrial genome sequencing showed that all maternal members carried a highly conserved m.4435A>G mutation. The m.4435A>G mutation might affect the secondary structure and folding free energy of mitochondrial tRNA and change its stability, which may influence the anticodon ring structure. Compared with the control group, the cell lines carrying m.4435A>G and

conclusionsThe

Indexed as

Essential HypertensionMutationRNA, Transfer, MetTyrosine-tRNA LigaseFemaleGenome, MitochondrialHumansMaleMembrane Potential, MitochondrialMitochondriaReactive Oxygen SpeciesRNA, TransferReactive Oxygen SpeciesRNA, TransferRNA, Transfer, MetTyrosine-tRNA LigaseYARS2 protein, humanEssential hypertensionGene mutationMaternal inheritanceMitochondrial DNAMitochondrial dysfunctionRespiratory chain

Identifiers

PMID38562030
PMCPMC11057996
OpenAlexW4394764745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.