Evidence map›Paper›PMID 38561955›Full record

ArticleAnnals of clinical and translational neurology2024

7T MRI detects widespread brain iron deposition in neuroferritinopathy.

Alexander G Murley, Catarina Rua, Heather Biggs, Christopher T Rodgers, Tomasz Matys, Jelle van den Ameele, Rita Horvath, Patrick F Chinnery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Neurodegeneration with Brain Iron Accumulation.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander G MurleyDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0813-0670
Catarina RuaWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0404-4399
Heather BiggsDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Christopher T RodgersDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1275-1197
Tomasz MatysDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2285-5715
Jelle van den AmeeleDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2744-0810
Rita HorvathDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9841-170X
Patrick F ChinneryDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7065-6617
University of Cambridge · GB

Funding

Alzheimer's Society AS-PG-18b-022Wellcome Trust 109915/Z/15/ZWellcome Trust 212219/Z/18/ZWellcome Trust 219615Wellcome Trust 226653
6 · The paper itself

Abstract

Neuroferritinopathy is a disorder of neurodegeneration with brain iron accumulation that has no proven disease-modifying treatments. Clinical trials require biomarkers of iron deposition. We examined brain iron accumulation in one presymptomatic FTL mutation carrier, two individuals with neuroferritinopathy and one healthy control using ultra-high-field 7T MRI. There was increased magnetic susceptibility, suggestive of iron deposition, in superficial and deep gray matter in both presymptomatic and symptomatic neuroferritinopathy. Cavitation of the putamen and globus pallidus increased with disease stage and at follow up. The widespread brain iron deposition in presymptomatic and early disease provides an opportunity for monitoring disease-modifying intervention.

Indexed as

IronIron Metabolism DisordersMagnetic Resonance ImagingNeuroaxonal DystrophiesAdultApoferritinsBrainFemaleHumansMaleMiddle AgedApoferritinsIron

Identifiers

PMID38561955
PMCPMC11093244
OpenAlexW4393484449

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.