Evidence map›Paper›PMID 38561854›Full record

ArticleMaternal health, neonatology and perinatology2024

Perinatal dengue and Zika virus cross-sectional seroprevalence and maternal-fetal outcomes among El Salvadoran women presenting for labor-and-delivery.

Mary K Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F Torres-Romero, Hanson Cowan, Madeleine M Meyer, Willber David Castro Godoy, Mufaro Kanyangarara, Stella C W Self and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal health, neonatology and perinatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mary K LynnDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA.
Marvin Stanley Rodriguez AquinoHealth Research and Development Center (CENSALUD), University of El Salvador, San Salvador, El Salvador.
Pamela Michelle Cornejo RivasHealth Research and Development Center (CENSALUD), University of El Salvador, San Salvador, El Salvador.
Xiomara MirandaHospital Nacional "Dr Jorge Mazzini Villacorta", Ministerio de Salud, Sonsonate, El Salvador.
David F Torres-RomeroDepartment of Chemistry and Pharmacy, University of El Salvador, Sonsonate, El Salvador.
Hanson CowanDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA.
Madeleine M MeyerDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA.
Willber David Castro GodoyHealth Research and Development Center (CENSALUD), University of El Salvador, San Salvador, El Salvador.
Mufaro KanyangararaDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA.
Stella C W SelfDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA.
Berry A CampbellDepartment of Obstetrics and Gynecology, Prisma Health, Columbia, SC, USA.
Melissa S NolanDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street #327, 29201, Columbia, SC, USA. msnolan@mailbox.sc.edu.
University of South Carolina · USUniversity of El Salvador · SVMinistry of Health · SVPrisma Health · USUniversidad de Sonsonate · SV

Funding

UofSC Maternal-Child Health Catalyst Graduate Scholars program sponsored by the Health Resources and Services Administration T1CMC35361
6 · The paper itself

Abstract

backgroundDespite maternal flavivirus infections' linkage to severe maternal and fetal outcomes, surveillance during pregnancy remains limited globally. Further complicating maternal screening for these potentially teratogenic pathogens is the overwhelming subclinical nature of acute infection. This study aimed to understand perinatal and neonatal risk for poor health outcomes associated with flaviviral infection during pregnancy in El Salvador.

methodsBanked serologic samples and clinical results obtained from women presenting for labor and delivery at a national referent hospital in western El Salvador March to September 2022 were used for this study. 198 samples were screened for dengue and Zika virus IgM, and statistical analyses analyzed demographic and clinical outcome associations with IgM positivity.

resultsThis serosurvey revealed a high rate of maternal flavivirus infection-24.2% of women presenting for labor and delivery were dengue or Zika virus IgM positive, suggesting potential infection within pregnancy. Specifically, 20.2% were Zika virus IgM positive, 1.5% were dengue virus IgM positive, and 2.5% were both dengue and Zika virus IgM positive. Women whose home had received mosquito abatement assistance within the last year by the ministry of health were 70% less likely to test IgM positive (aOR = 0.30, 95%CI: 0.10, 0.83). Further, statistical geospatial clustering revealed transmission foci in six primary municipalities. Pregnancy complications and poor birth outcomes were noted among the dengue and/or Zika virus maternal infection group, although these outcomes were not statistically different than the seronegative group. None of the resulting neonates born during this study were diagnosed with congenital Zika syndrome.

conclusionsThe high rate of Zika virus detected among pregnant women and the lack of Zika-specific neonatal outcomes monitoring during a non-outbreak year highlights the need for continued surveillance in Central America and among immigrant mothers presenting for childbirth from these countries. As changing climatic conditions continue to expand the range of the disease vector, asymptomatic screening programs could be vital to early identification of outbreaks and clinical management of cases.

Indexed as

Dengue virusEl SalvadorFlavivirusHealth disparitiesHealth outcomesMaternal-fetal medicineParturitionZika virus

Identifiers

PMID38561854
PMCPMC10985905
OpenAlexW4393393615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.