Evidence map›Paper›PMID 38561747›Full record

ReviewJournal of cardiothoracic surgery2024

Mediastinal Rosai-Dorfman Disease with KRAS mutation case report and literature review.

Wenyu Zhang, Linan Fang, Jing Wang, Xiaobo Ma, Xintong Hu, Wei Liu

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wenyu ZhangDepartment of Thoracic Surgery, the First Hospital of Jilin University, Changchun, Jilin, China.
Linan FangDepartment of Thoracic Surgery, the First Hospital of Jilin University, Changchun, Jilin, China.
Jing WangDepartment of Radiology, the First Hospital of Jilin University, Changchun, Jilin, China.
Xiaobo MaDepartment of Pathology, the First Hospital of Jilin University, Changchun, Jilin, China.
Xintong HuGenetic Diagnosis Center, the First Hospital of Jilin University, Changchun, Jilin, China.
Wei LiuDepartment of Thoracic Surgery, the First Hospital of Jilin University, Changchun, Jilin, China. l_w01@jlu.edu.cn.
First Hospital of Jilin University · CNJilin University · CN

Funding

National Natural Science Foundation of China #82003284Scientific Research Foundation of The First Hospital of Jilin University #JDYY11202015
6 · The paper itself

Abstract

backgroundRosai-Dorfman Disease (RDD) is a rare self-limiting histiocytosis, more prevalent in children and young adults. It typically manifests as painless bilateral massive cervical lymphadenopathy but may also extend to extra-nodal sites, with intrathoracic RDD noted in 2% of cases. Distinguishing mediastinal RDD from thymoma on imaging poses challenges, underscoring the reliance on pathological features and immunohistochemical staining for diagnosis. CASE PRESENTATION: Patient, male, 33 years old, underwent lung a CT revealing an enlarged round soft tissue shadow in the anterior superior mediastinum, compared to a year ago. Surgical resection removed the entire mass, thymus, and part of the pericardium, confirming RDD on pathology. Genetic testing using second-generation testing technology identified a KRAS gene point mutation.

conclusionsNo established treatment protocol currently exists for this disease. However, as genetic mutation research progresses, a novel therapeutic avenue is emerging: targeted therapy integrated with surgical interventions.

Indexed as

Histiocytosis, SinusAdultHumansMaleMediastinumMutationProto-Oncogene Proteins p21(ras)ThoraxKRAS protein, humanProto-Oncogene Proteins p21(ras)ImmunohistochemistryKRAS mutationMediastinal diseasesRosai–Dorfman diseaseSinus histiocytosis with massive lymphadenopathy

Identifiers

PMID38561747
PMCPMC10985954
OpenAlexW4393386670

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.