Evidence map›Paper›PMID 38561621›Full record

Trial reportReviews on recent clinical trials2024

Effect of Iron Deficiency Anemia on Blood Glucose and Insulin Resistance in Women with Type II Diabetes: A Single-group, Clinical Interventional Study.

Mahmoud Parham, Gholam Reza Tavasoli, Shahram Arsang-Jang, Mohammad Amin Habibi, Davood Olad Dameshgi, Mohammad Reza Pashaei, Sajjad Ahmadpour, Jamshid Vafaeimanesh

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In one paragraph

Trial report in Reviews on recent clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mahmoud ParhamClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Gholam Reza TavasoliClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Shahram Arsang-JangDepartment of Epidemiology and Biostatistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Mohammad Amin HabibiDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Davood Olad DameshgiClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Mohammad Reza PashaeiPatient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Sajjad AhmadpourPatient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Jamshid VafaeimaneshClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Qom University of Medical Science and Health Services · IRUrmia University · IRShariati Hospital · IRZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIron deficiency anemia (IDA) is one of the disorders recently associated with an increase in insulin resistance (IR) and, consequently, diabetes mellitus (DM) affection by causing oxidative stress. In this study, we look at how IDA may contribute to developing type II diabetes mellitus (T2DM), controlling diabetes, and reducing IR in women with T2DM.

methodsIn this single group, clinical interventional study, we enrolled 40 women with T2DM and IDA. Before and after intervention with ferrous sulfate tablets, their blood glucose (BG) levels and IR levels were evaluated. This study was approved by the Ethics Committee of Qom University of Medical Sciences (ethics code: IR.MUQ.REC.1397.031) and registered at the Iranian Center for Clinical Trials (No. IRCT20170215032587N3). A significant level was considered p <0.05.

resultThe mean age of patients was 48.18 ± 4.6 years, with 5.3-5.8 years duration of T2DM. After the intervention, the mean fasting blood glucose (FBG) level reached 198.53 ± 48.11 to 170.93 ± 37.41, which was significant (p <0.0001). Also, hemoglobin A1C level reached from 8.49 ± 0.9 to 7.96 ± 0.58, which was significant (p <0.0001). Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) demonstrating a significant reduction of IR levels after intervention with ferrous sulfate tablets (p <0.018).

conclusionsIDA treatment in patients with T2DM can significantly reduce the BG and IR levels. To better control BG, checking iron status and its correction may provide better clinical outcomes in these patients.

Indexed as

Anemia, Iron-DeficiencyBlood GlucoseDiabetes Mellitus, Type 2Ferrous CompoundsInsulin ResistanceAdultFemaleHumansIranMiddle AgedBlood GlucoseFerrous Compoundsferrous sulfatefasting blood glucose.hemoglobin A1Cinsulin resistanceIron deficiency anemiatype 2 diabetes mellitus

Identifiers

PMID38561621
OpenAlexW4393444678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.