Evidence map›Paper›PMID 38561566›Full record

ArticleDrug delivery and translational research2024

Immunomodulatory potential of rapamycin-loaded mesoporous silica nanoparticles: pore size-dependent drug loading, release, and in vitro cellular responses.

Ana M Pérez-Moreno, Carlos J Aranda, María José Torres, Cristobalina Mayorga, Juan L Paris

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ana M Pérez-MorenoAllergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina- IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain.
Carlos J ArandaAllergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina- IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain.
María José TorresAllergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina- IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain.
Cristobalina MayorgaAllergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina- IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain. lina.mayorga@ibima.eu.
Juan L ParisAllergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina- IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain. juan.paris@ibima.eu.ORCID 0000-0001-8950-283X
Instituto de Investigación Biomédica de Málaga · ESHospital Regional Universitario de Málaga · ES

Funding

Agencia Estatal de Investigación PID2022-142781OA-I00Agencia Estatal de Investigación RYC2021-034536-IConsejería de Salud y Consumo, Junta de Andalucía RC0004-2021HORIZON EUROPE Excellent Science 101105416Instituto de Salud Carlos III CD21/00034Instituto de Salud Carlos III PI21/00346Instituto de Salud Carlos III RD21/0002/0008
6 · The paper itself

Abstract

Rapamycin is a potent immunosuppressive drug that has been recently proposed for a wide range of applications beyond its current clinical use. For some of these proposed applications, encapsulation in nanoparticles is key to ensure therapeutic efficacy and safety. In this work, we evaluate the effect of pore size on mesoporous silica nanoparticles (MSN) as rapamycin nanocarriers. The successful preparation of MSN with 4 different pore sizes was confirmed by dynamic light scattering, zeta potential, transmission electron microscopy and N

Indexed as

Dendritic CellsDrug LiberationNanoparticlesSilicon DioxideSirolimusAnimalsCell LineCell SurvivalDrug CarriersImmunomodulating AgentsImmunosuppressive AgentsMicePorosityDrug CarriersImmunomodulating AgentsImmunosuppressive AgentsSilicon DioxideSirolimusDendritic cellsImmunomodulationMesoporous silica nanoparticlesNanomedicineRapamycin

Identifiers

PMID38561566
PMCPMC11499431
OpenAlexW4393377448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.