Evidence map›Paper›PMID 38561494›Full record

ReviewArchives of pharmacal research2024

Potential biological functions and future perspectives of sialylated milk oligosaccharides.

Thuy Le Lam Nguyen, Dung Van Nguyen, Kyung-Sun Heo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of pharmacal research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Protective effect of 6'-Sialyllactose on LPS-induced macrophage inflammationThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thuy Le Lam NguyenCollege of Pharmacy, Chungnam National University, Daejeon, South Korea.
Dung Van NguyenCollege of Pharmacy, Chungnam National University, Daejeon, South Korea.
Kyung-Sun HeoCollege of Pharmacy, Chungnam National University, Daejeon, South Korea. kheo@cnu.ac.kr.ORCID http://orcid.org/0000-0003-3800-7665

Funding

National Research Foundation of Korea 2022R1A2C40017761231482092640102
6 · The paper itself

Abstract

Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and potential biological effects of SLs, with a specific focus on their influence across various physiological systems, including the gastrointestinal system, immune disorders, rare genetic disorders (such as GNE myopathy), cancers, neurological disorders, cardiovascular diseases, diverse cancers, and viral infections, thus indicating their therapeutic potential.

Indexed as

MilkMilk, HumanOligosaccharidesAnimalsCattleHumansLactose3'-sialyllactose6'-sialyllactoseLactoseOligosaccharidesBiological effectsHuman milk oligosaccharidesSafetySialyllactoseSynthesis

Identifiers

PMID38561494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.