ArticleBritish journal of cancer2024
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.
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Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Global, regional, national burden of colorectal cancer from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021.Frontiers in oncology · 2025Pooled it
- Sex differences in non-reproductive cancers: mechanistic roles of sex-hormone signaling.Cell communication and signaling : CCS · 2026Review
- Menopause Hormone Therapy in Women With Cardiovascular Risk Factors or Established Ischemic Heart Disease: A Joint FIGO and WHF Position Paper.Global heart · 2026Review
- Menopausal Hormone Therapy-Risks, Benefits and Emerging Options: A Narrative Review.International journal of molecular sciences · 2025Review
- CK2α Overexpression in Colorectal Cancer: Evidence for Sex- and Age-Linked Differences.Cancers · 2025Article
- Menopause and gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk.JNCI cancer spectrum · 2025Article
- Effect of Menopausal Hormone Therapy on Cellular Immunity Parameters and Cytokine Profile.Biomedicines · 2024Article
- 17β-estradiol in colorectal cancer: friend or foe?Cell communication and signaling : CCS · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
78 authors at 20 institutions in 16 countries.
Yu Tian *School of Public Health, Capital Medical University, Beijing, China.ORCID 0000-0001-7218-5954
Yi Lin *Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
James W BaurleyBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
D Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.ORCID 0000-0002-8752-8785
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6129-1572
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0003-2225-6675
Arif BudiartoBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Robert Carreras-TorresColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2925-734X
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7284-6767
Rui ChenSchool of Public Health, Capital Medical University, Beijing, China.
Xuechen ChenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-2476-7110
David V ContiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2941-7833
Virginia Díez-ObreroColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Niki DimouNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
David A DrewClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Stephen B GruberDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0001-8656-7822
Marc J GunterNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0001-8540-6891
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Akihisa HidakaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0001-6027-9806
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Kristina M JordahlPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Amit D JoshiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Eric KawaguchiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andre E KimDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, CA, USA.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-0118-0341
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Juan Pablo LewingerDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Victor MorenoColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2818-5487
John MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Neil MurphyNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-3347-8249
Hongmei NanDepartment of Global Health, Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia.ORCID 0000-0001-9914-7851
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0001-8786-0043
Mireia Obón-SantacanaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Shuji OginoBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-3909-2323
Jennifer OseHuntsman Cancer Institute, Salt Lake City, UT, USA.
Bens PardameanBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.ORCID 0000-0002-7404-9005
Andrew J PellattDepartment of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0127-9790
Anita R PeoplesHuntsman Cancer Institute, Salt Lake City, UT, USA.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-3676-8954
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ross L PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-0339-5824
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Anna ShcherbinaBiomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.
Mariana C SternDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yu-Ru SuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Duncan C ThomasDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Franzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0582-8005
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada.
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
W James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. lih@fredhutch.org.ORCID 0000-0001-8168-4712
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. j.chang-claude@dkfz.de.ORCID 0000-0001-8919-1971
University of Southern California · USFred Hutch Cancer Center · USUniversity of Washington · USGerman Cancer Research Center · DEBellvitge University Hospital · ESBinus University · IDCentre international de recherche sur le cancer · FRBroad Institute · USHarvard University · USJohns Hopkins University · USKarolinska Institutet · SEStanford University · USThe University of Melbourne · AUUmeå University · SEAlbert Einstein College of Medicine · USCapital Medical University · CNCity Of Hope National Medical Center · USHochschule Hannover · DEKaiser Permanente · USKaiser Permanente Washington Health Research Institute · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MTranslational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MUSC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization StudiesU2CCA252971 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JOHN D. CARPTEN, HEINZ JOSEF LENZ · 2021 to 2026
$19.3MNational Natural Science Foundation of China (National Science Foundation of China) 82204127NCI NIH HHS K05 CA152715NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA066635NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA097325NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA242218NCI NIH HHS R01 CA263318NCI NIH HHS R03 CA153323NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA086308NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA261339NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074794NCI NIH HHS U2C CA252971NCI NIH HHS UM1 CA186107NCI NIH HHS Z01 CP010200NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIA NIH HHS U01 AG018033NIDDK NIH HHS K01 DK120742NIDDK NIH HHS K24 DK098311NIDDK NIH HHS P30 DK034987NIEHS NIH HHS T32 ES013678NIH HHS S10 OD028685World Health Organization 001
Abstract
backgroundMenopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk.
methodsWe used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated.
resultsThe reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (p-value = 2.7 × 10
conclusionsMHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk prediction models for CRC and potentially for the consideration of genetic information in the risk-benefit assessment of MHT use.
Indexed as
Colorectal NeoplasmsGenetic Predisposition to DiseaseAgedCase-Control StudiesEstrogen Replacement TherapyFemaleHormone Replacement TherapyHumansMenopauseMiddle AgedPostmenopauseRisk AssessmentRisk Factors
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