ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization.Neural regeneration research · 2026Article
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- Chronic stress enhances threat responding and impacts fear extinction.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Flexible Coupling of Synaptic and Intrinsic Plasticity in a Cerebellar Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Learning, sleep replay and consolidation of contextual fear memories: A neural network model.PLoS computational biology · 2026Article
- Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- The contributing role of CCR5 in dementia.Frontiers in neurology · 2025Review
- Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry.Molecular brain · 2024Article
- The Role of Intrinsic Plasticity in Engram Physiology and Temporal Memory Linking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.