Evidence map›Paper›PMID 38561169›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2024

Association between sleep-disordered breathing and post-stroke fatigue in patients with ischemic stroke.

Christopher J Becker, Lynda D Lisabeth, Madeline Kwicklis, Xu Shi, Ronald D Chervin, Erin Case, Devin L Brown

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Impacts of obstructive sleep apnea on collateral circulation in stroke patients with proximal middle cerebral artery stenosis or occlusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher J BeckerDepartment of Neurology, University of Michigan. Electronic address: cbec@med.umich.edu.
Lynda D LisabethDepartment of Epidemiology, School of Public Health, University of Michigan.
Madeline KwicklisDepartment of Epidemiology, School of Public Health, University of Michigan.
Xu ShiDepartment of Biostatistics, School of Public Health, University of Michigan.
Ronald D ChervinSleep Disorders Center and Department of Neurology, University of Michigan.
Erin CaseDepartment of Neurology and Department of Epidemiology, School of Public Health, University of Michigan.
Devin L BrownDepartment of Neurology, University of Michigan.
University of Michigan–Ann Arbor · US

Funding

STROKE SURVEILLANCE IN A BIETHNIC COMMUNITYR01NS038916 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LISABETH, LYNDA D, MORGENSTERN, LEWIS B · 1999 to 2023
$20.9M
Brain Attack Surveillance in Corpus Christi (BASIC) ProjectR37NS038916 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYNDA D LISABETH, LEWIS B MORGENSTERN · 2024 to 2026
$3.7M
Sleep apnea after stroke: Implications for screening and treatmentR01HL126700 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2016 to 2019
$3.0M
NHLBI NIH HHS R01 HL126700NINDS NIH HHS R01 NS038916NINDS NIH HHS R37 NS038916
6 · The paper itself

Abstract

objectivesPost-stroke fatigue (PSF) is common and often disabling. Sleep-disordered breathing (SDB) is highly prevalent among stroke survivors and can cause fatigue. We explored the relationship between SDB and PSF over time. MATERIALS AND

methodsIschemic stroke (IS) patients within the BASIC project were offered SDB screening with a well-validated cardiopulmonary sleep apnea test at 0, 3-, 6-, and 12-months post-stroke. The primary exposure was the respiratory event index (REI; sum of apneas plus hypopneas per hour). The primary outcome was PSF, measured by the SF-36 vitality scale. Associations between REI and PSF were evaluated using linear regression including time-by-REI interactions, allowing the effect of REI to vary over time.

resultsOf the 411 IS patients who completed at least one outcome interview, 44 % were female, 61 % Mexican American (MA), 26 % non-Hispanic white, with a mean age of 64 (SD 10). Averaged across timepoints, REI was not associated with PSF. In a time-varying model, higher REI was associated with greater PSF at 3-months (β = 1.75, CI = 0.08, 3.43), but not at 6- or 12-months. Across timepoints, female sex, depressive symptoms, and comorbidity burden were associated with greater PSF, whereas MA ethnicity was associated with less PSF.

conclusionsHigher REI was associated with modestly greater PSF in the early post-stroke period, but no association was observed at 6 months and beyond. SDB may be a modest modifiable risk factor for early PSF, but its treatment is unlikely to have a substantial impact on long-term PSF. MA ethnicity seems to be protective against PSF.

Indexed as

FatigueIschemic StrokeSleep Apnea SyndromesAgedFemaleHumansMaleMiddle AgedPrognosisRespirationRisk AssessmentRisk FactorsSleepTime FactorsEthnicityPost-stroke fatigueSleep apneaSleep disordered breathing

Identifiers

PMID38561169
PMCPMC11088507
OpenAlexW4393336500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.