Evidence map›Paper›PMID 38561043›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024

Carriage of antimicrobial-resistant Enterobacterales among pregnant women and newborns in Amhara, Ethiopia.

Getnet Amsalu, Christine Tedijanto Wen, Olga Perovic, Addisalem Gebru, Bezawit M Hunegnaw, Fisseha Tadesse, Marshagne Smith, Addisalem Fikre, Delayehu Bekele, Lisanu Taddesse and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Extended spectrum beta lactamases and carbapenemase-producingOne health (Amsterdam, Netherlands) · 2026
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Getnet AmsaluBirhan HDSS, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia; HaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia.
Christine Tedijanto WenSurgo Health, Washington, DC, USA.
Olga PerovicCentre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa; Department of Clinical Microbiology and Infectious Diseases, University of Witwatersrand, Johannesburg, South Africa.
Addisalem GebruBirhan HDSS, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia; HaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia; Department of Obstetrics and Gynecology, Debre Birhan Hospital, Debre Birhan, Ethiopia.
Bezawit M HunegnawHaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia; Department of Pediatrics and Child Health, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Fisseha TadesseDepartment of Obstetrics and Gynecology, Debre Birhan Hospital, Debre Birhan, Ethiopia.
Marshagne SmithCentre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa.
Addisalem FikreBirhan HDSS, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia; HaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia.
Delayehu BekeleDepartment of Obstetrics and Gynecology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lisanu TaddesseHaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia.
Grace J ChanDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: grace.chan@childrens.harvard.edu.
Kantar Health (United States) · USDebre Berhan University · ETNational Health Laboratory Service · ZABoston Children's Hospital · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInfections are one of the most common causes of neonatal mortality, and maternal colonization has been associated with neonatal infection. In this study, we sought to quantify carriage prevalence of extended-spectrum-beta-lactamase (ESBL) -producing and carbapenem-resistant Enterobacterales (CRE) among pregnant women and their neonates and to characterize risk factors for carriage in rural Amhara, Ethiopia.

methodsWe conducted a prospective cohort study nested in the Birhan field site. We collected rectal and vaginal samples from 211 pregnant women in their third trimester and/or during labor/delivery and perirectal or stool samples from 159 of their neonates in the first week of life.

resultsWe found that carriage of ESBL-producing organisms was fairly common (women: 22.3%, 95% CI: 16.8-28.5; neonates: 24.5%, 95% CI: 18.1-32.0), while carriage of CRE (women: 0.9%, 95% CI: 0.1-3.4; neonates: 2.5%, 95% CI: 0.7-6.3) was rare. Neonates whose mothers tested positive for ESBL-producing organisms were nearly twice as likely to also test positive for ESBL-producing organisms (38.7% vs 21.1%, P-value = 0.06). Carriage of ESBL-producing organisms was also associated with Woreda (district) of sample collection and recent antibiotic use.

conclusionUnderstanding carriage patterns of potential pathogens and antibiotic susceptibility among pregnant women and newborns will inform local, data-driven recommendations to prevent and treat neonatal infections.

Indexed as

Anti-Bacterial Agentsbeta-LactamasesCarrier StateEnterobacteriaceaeEnterobacteriaceae InfectionsPregnancy Complications, InfectiousAdolescentAdultEthiopiaFecesFemaleHumansInfant, NewbornMicrobial Sensitivity TestsPregnancyPrevalenceAnti-Bacterial Agentsbeta-LactamasesAntibiotic resistanceCarbapenem-resistant EnterobacteralesExtended-spectrum-beta-lactamase-producing organismsNeonatesSepsisVertical transmission

Identifiers

PMID38561043
PMCPMC11068590
OpenAlexW4393343032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.