ArticleJournal of rheumatic diseases2024
Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis.
Article in Journal of rheumatic diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 9 of them syntheses that pooled it.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 9 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Comparative efficacy and safety of denosumab biosimilar and originator in postmenopausal osteoporosis: a meta-analysis of randomized controlled trials.Zeitschrift fur Rheumatologie · 2026Pooled it
- Systemic immune-inflammation index and systemic inflammation response index in systemic lupus erythematosus: a meta-analysis.Zeitschrift fur Rheumatologie · 2026Pooled it
- Indirect comparative efficacy and safety of belimumab vs. anifrolumab in systemic lupus erythematosus and lupus nephritis: a meta-analysis of randomized trials.Zeitschrift fur Rheumatologie · 2026Pooled it
- Association between TNF-α polymorphisms and responsiveness to TNF-α blockers in ankylosing spondylitis and psoriatic arthritis: a meta-analysis.Scientific reports · 2026Pooled it
- Cancer risk across sex, region, and disease subtype in ANCA-associated vasculitis patients : A meta-analysis.Zeitschrift fur Rheumatologie · 2025Pooled it
- Diagnostic accuracy of ferritin and glycosylated ferritin in adult-onset Still's disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2025Pooled it
- Diagnostic accuracy of IgG 4/IgG and IgG 4 in patients with IgG 4-related disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2025Pooled it
- Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis.PloS one · 2025Pooled it
- Effect of urate-lowering therapy on all-cause and CVD-specific mortality in gout and hyperuricemia: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: While urate-lowering therapy (ULT) is linked to increased cardioprotective benefits on primary prevention of cardiovascular events such myocardial infarction or heart failure, little is known regarding their effects on arrhythmia risk. The purpose of this study was to investigate the relationship between incident arrhythmias and ULT. Methods: We searched MEDLINE and Embase from inception to May 2023. Included studies were randomized controlled trials and cohort studies that compared the risk of cardiac arrhythmias among ULT users with non-ULT users. Results: A total of 12,420 patients from five studies were analyzed, comprising 7,359 subjects in the ULT group and 5,061 subjects in the non-ULT group. Our results showed that ULT users had significant reductions in the risk of arrhythmias (pooled relative risk [RR] 0.82, 95% confidence interval [CI] 0.74~0.92, p<0.001, I2=0.0%) compared to non-ULT users. Subgroup analysis did not show that ULT users had a significant reduced risk of atrial fibrillation (pooled RR 0.76, 95% CI 0.54~1.05, p=0.096 with I2=15.4%) compared to non-ULT users. Conclusion: ULT is associated with lower risk of overall arrhythmias. Further studies are warranted to confirm our findings.
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