ReviewDigital health
Digital technologies used in clinical trial recruitment and enrollment including application to trial diversity and inclusion: A systematic review.
Review in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Feasibility of EHR-based prescreening for an adjuvant breast cancer trial in a safety-net health system.The oncologist · 2026Article
- Barriers and Facilitators to Intracerebral Haemorrhage Platform Trial Recruitment: A Survey of Stroke Clinicians.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Recruitment Strategies in Registry-Based Observational Research: A Single-Center Experience in the United States from the HeartShare Study.Journal of cardiac failure - intersections · 2026Article
- Keeping Clinical Trials on an Inclusive Track.Journal of medical Internet research · 2026Article
- Direct-to-Participant Enrollment in a Virtual Trial: Lessons Learned From the Heartline Study.JACC. Advances · 2026Article
- The ESMO/SIOG Cancer in the Elderly Working Group pragmatic strategies for clinical trial designs and endpoints in older adults with cancer.ESMO open · 2026Review
- Sociodemographic Drivers of Recruitment and Attrition in Digital Neurological Research: Longitudinal Cohort Study.Journal of medical Internet research · 2026Observational
- The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians.NPJ digital medicine · 2026Review
- Decentralized Clinical Trials: Governance, Ethics and Medico-Legal Issues for the New Paradigm of Research with a Focus on Cardiovascular Field.Medical sciences (Basel, Switzerland) · 2025Review
- Representation is power: traditional, hybrid, and digital recruitment results from a non-randomized clinical trial engaging adolescents.NPJ digital medicine · 2025Article
- Review
- Who Makes It Through the Funnel? Sociodemographic Drivers of Recruitment Completion into an AI-Ready Digital Speech Bank.medRxiv : the preprint server for health sciences · 2025Article
- Enrollment and Retention Outcomes from the Veterans Health Administration for a Remote Digital Health Study: Multisite Observational Study.JMIR formative research · 2025Observational
- Recruitment and Retention Strategies in Clinical Trials for Hip Fractures: A Cross-Sectional Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Approach to Design and Evaluate Digital Tools to Enhance Young Adult Participation in Clinical Trials: Co-Design and Controlled Intercept Study.Journal of medical Internet research · 2025Article
- Article
- Tailoring implementation strategies for the healthy actions and lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program: Lessons learned from a survey study.The journal of prevention of Alzheimer's disease · 2025Article
- Blockchain-enabled quality by design system for clinical trials.Frontiers in medicine · 2025Article
- Population health management of human phenotype ontology.Frontiers in artificial intelligence · 2025Article
- Leveraging Social Determinants of Health to Enhance Recruitment of Underrepresented Populations in Clinical Trials.Methodist DeBakey cardiovascular journal · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Many clinical trials fail because of poor recruitment and enrollment which can directly impact the success of biomedical and clinical research outcomes. Options to leverage digital technology for improving clinical trial management are expansive, with potential benefits for improving access to clinical trials, encouraging trial diversity and inclusion, and potential cost-savings through enhanced efficiency. Objectives: This systematic review has two key aims: (1) identify and describe the digital technologies applied in clinical trial recruitment and enrollment and (2) evaluate evidence of these technologies addressing the recruitment and enrollment of racial and ethnic minority groups. Methods: We conducted a cross-disciplinary review of articles from PubMed, IEEE Xplore, and ACM Digital Library, published in English between January 2012 and July 2022, using MeSH terms and keywords for digital health, clinical trials, and recruitment and enrollment. Articles unrelated to technology in the recruitment/enrollment process or those discussing recruitment/enrollment without technology aspects were excluded. Results: The review returned 614 results, with 21 articles (four reviews and 17 original research articles) deemed suitable for inclusion after screening and full-text review. To address the first objective, various digital technologies were identified and characterized, which included articles with more than one technology subcategory including (a) multimedia presentations (19%, Conclusion: Results from this review illustrate that several types of technology are currently being explored and utilized in clinical trial recruitment and enrollment stages. However, evidence supporting the use of digital technologies is varied and requires further research and evaluation to identify the most valuable opportunities for encouraging diversity in clinical trial recruitment and enrollment practices.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.