Evidence map›Paper›PMID 38559276›Full record

ArticlebioRxiv : the preprint server for biology2024

The β2-adrenergic receptor (ADRB2) entrains circadian gene oscillation and diurnal responses to virus infection in CD8

Drashya Sharma, Kira A Kohlbach, Robert Maples, J David Farrar

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Drashya Sharma
Kira A Kohlbach
Robert Maples
J David Farrar
The University of Texas Southwestern Medical Center · US

Funding

Adrenergic control of circadian rhythms in CD8 T cells responding to influenzaR01AI175217 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI John David FARRAR · 2023 to 2026
$2.3M
Adrenergic Control of Memory T Cells by Circadian RhythmsR21AI143248 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI FARRAR, JOHN DAVID · 2019 to 2020
$446k
NIAID NIH HHS R01 AI175217NIAID NIH HHS R21 AI143248
6 · The paper itself

Abstract

Adaptive immune cells are regulated by circadian rhythms (CR) under both steady state conditions and during responses to infection. Cytolytic CD8 One Sentence Summary: The β2-adrenergic receptor regulates circadian gene oscillation and downstream daily timing of cytolytic T cell responses to virus infection.

Identifiers

PMID38559276
PMCPMC10980027
OpenAlexW4392809185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.