Evidence map›Paper›PMID 38559264›Full record

ArticlebioRxiv : the preprint server for biology2024

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the frontal cortex.

Rianne Stowell, Kuan Hong Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rianne StowellDepartment of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, 14642.ORCID 0000-0002-6060-1313
Kuan Hong WangDepartment of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, 14642.
University of Rochester Medical Center · US

Funding

Fronto-insular network in cognitive-affective interactions during decision-makingR01MH127737 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Kuan Hong Wang, Yi Zuo · 2022 to 2026
$2.8M
Adolescent plasticity of the dopaminergic mesofrontal circuit: cellular mechanisms and behavioral rolesF32MH124298 · NIMH · UNIVERSITY OF ROCHESTER · PI STOWELL, RIANNE · 2021 to 2022
$143k
NIMH NIH HHS F32 MH124298NIMH NIH HHS R01 MH127737
6 · The paper itself

Abstract

Adolescence is a sensitive period for frontal cortical development and cognitive maturation. The dopaminergic (DA) mesofrontal circuit is particularly malleable in response to changes in adolescent experience and DA activity. However, the cellular mechanisms engaged in this plasticity remain unexplored. Here, we report that microglia, the innate immune cells of the brain, are uniquely sensitive to adolescent mesofrontal DA signaling. Longitudinal

Identifiers

PMID38559264
PMCPMC10979918
OpenAlexW4392761821

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.