Evidence map›Paper›PMID 38559258›Full record

ArticleResearch square2024

Investigating the Role of Thrombosis, Fenestration, and False Lumen Orbital Orientation in the Hemodynamics of Type B Aortic Dissection.

Joseph C E Messou, Kelly Yeung, Eric Sudbrook, Jackie Zhang, Shahab Toursavadkohi, Areck A Ucuzian, Eleonora Tubaldi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph C E MessouDepartment of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
Kelly YeungFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Eric SudbrookDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
Jackie ZhangDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.
Shahab ToursavadkohiDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.
Areck A UcuzianDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.
Eleonora TubaldiDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
University of Maryland, Baltimore · USUniversity of Maryland, College Park · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Mechanisms of aortopathy in LRP1 deficiencyK08HL146893 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI UCUZIAN, ARECK A · 2020 to 2024
$816k
NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K08 HL146893
6 · The paper itself

Abstract

While much about the fundamental mechanisms behind the initiation and progression of Type B aortic dissection (TBAD) is still unknown, predictive models based on patient-specific computational fluid dynamics (CFD) can help in risk stratification and optimal clinical decision-making. Aiming at the development of personalized treatment, CFD simulations can be leveraged to investigate the interplay between complex aortic flow patterns and anatomical features. In this study, the hemodynamics of false lumen thrombosis, a large fenestration, and the orbital orientation of the false lumen is studied through image-based CFD simulations on three TBAD patient-specific geometries. A new pipeline was developed leveraging the open-source software SimVascular and Paraview to analyze multiple patients simultaneously and to achieve large-scale parallelization in CFD results based on patients' computed tomography (CT) images. The results of this study suggest that the internal orbital orientation of the false lumen contributes to maintaining a positive luminal pressure difference

Identifiers

PMID38559258
PMCPMC10980148
OpenAlexW4392854769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.